Sophie Lefèvre-Arbogast1, David Gaudout2, Julien Bensalem2, Luc Letenneur2, Jean-François Dartigues2, Boris P Hejblum2, Catherine Féart2, Cécile Delcourt2, Cécilia Samieri2. 1. From the University of Bordeaux, Inserm (S.L.-A., L.L., J.-F.D., B.P.H., C.F., C.D., C.S.), ISPED, Bordeaux Population Health Research Center, UMR 1219 Bordeaux, France; Activ'Inside (D.G., J.B.), Beychac et Caillau, France; Inria SISTM (B.P.H.), Bordeaux, France; and Department of Biostatistics (B.P.H.)., Harvard T.H. Chan School of Public Health, Boston, MA. Sophie.Lefevre-Arbogast@u-bordeaux.fr. 2. From the University of Bordeaux, Inserm (S.L.-A., L.L., J.-F.D., B.P.H., C.F., C.D., C.S.), ISPED, Bordeaux Population Health Research Center, UMR 1219 Bordeaux, France; Activ'Inside (D.G., J.B.), Beychac et Caillau, France; Inria SISTM (B.P.H.), Bordeaux, France; and Department of Biostatistics (B.P.H.)., Harvard T.H. Chan School of Public Health, Boston, MA.
Abstract
OBJECTIVE: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. METHODS: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. RESULTS: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models. CONCLUSIONS: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.
OBJECTIVE: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. METHODS: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. RESULTS: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models. CONCLUSIONS: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.
Authors: Catherine P Bondonno; Nicola P Bondonno; Frederik Dalgaard; Kevin Murray; Samantha L Gardener; Ralph N Martins; Stephanie R Rainey-Smith; Aedín Cassidy; Joshua R Lewis; Kevin D Croft; Cecilie Kyrø; Gunnar Gislason; Augustin Scalbert; Anne Tjønneland; Kim Overvad; Jonathan M Hodgson Journal: Alzheimers Dement (N Y) Date: 2021-05-13
Authors: David Vauzour; Catarina Rendeiro; Alfonsina D'Amato; Pierre Waffo-Téguo; Tristan Richard; Jean Michel Mérillon; Matthew G Pontifex; Emily Connell; Michael Müller; Laurie T Butler; Claire M Williams; Jeremy P E Spencer Journal: Antioxidants (Basel) Date: 2021-07-31