Xiang Guo1, Lingyun Gao1, Zhitao Shi1, Deguo Liu1, Yuhong Wang1, Zhanguo Sun1, Yueqin Chen2, Weijian Chen3, Yunjun Yang3. 1. Department of Medical Imaging, the Affiliated Hospital of Jining Medical University, Jining, China. 2. Department of Medical Imaging, the Affiliated Hospital of Jining Medical University, Jining, China. Electronic address: sdjnchenyueqin@163.com. 3. Department of Medical Imaging, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Abstract
BACKGROUND: Previous studies have been inconsistent regarding risk for intracranial aneurysm related to intracranial arterial fenestration. We conducted a meta-analysis to examine the association between intracranial arterial fenestration and risk of aneurysm. METHODS: We performed a systematic review of PubMed and Embase through August 2017 for potentially relevant articles. Summary odds ratios with 95% confidence intervals were pooled using a random-effects model. RESULTS: Of 446 articles found, 7 were selected for meta-analysis. Pooled odds ratios revealed an increased risk of aneurysm owing to fenestration of 1.50 (95% confidence interval, 0.61-3.71; P = 0.38). Subgroup analyses based on the population presenting with various indications suggested that pooled odds ratios indicated a significant increase in risk for aneurysm of 2.43 (95% confidence interval, 1.04-5.69; P = 0.04). CONCLUSIONS: Our findings indicate that intracranial arterial fenestration may be associated with increased risk for aneurysm formation.
BACKGROUND: Previous studies have been inconsistent regarding risk for intracranial aneurysm related to intracranial arterial fenestration. We conducted a meta-analysis to examine the association between intracranial arterial fenestration and risk of aneurysm. METHODS: We performed a systematic review of PubMed and Embase through August 2017 for potentially relevant articles. Summary odds ratios with 95% confidence intervals were pooled using a random-effects model. RESULTS: Of 446 articles found, 7 were selected for meta-analysis. Pooled odds ratios revealed an increased risk of aneurysm owing to fenestration of 1.50 (95% confidence interval, 0.61-3.71; P = 0.38). Subgroup analyses based on the population presenting with various indications suggested that pooled odds ratios indicated a significant increase in risk for aneurysm of 2.43 (95% confidence interval, 1.04-5.69; P = 0.04). CONCLUSIONS: Our findings indicate that intracranial arterial fenestration may be associated with increased risk for aneurysm formation.
Authors: I Capelli; M Zoli; M Righini; L Faccioli; V Aiello; L Spinardi; D Gori; F Friso; A Rustici; C Bortolotti; C Graziano; V Mantovani; N Sciascia; D Mazzatenta; M Seri; M Pastore Trossello; G La Manna Journal: Clin Neuroradiol Date: 2021-09-29 Impact factor: 3.649