| Literature DB >> 29702248 |
Graziela Domingues de Almeida Lima1, Marcela Nascimento Sertorio1, Ana Cláudia Ferreira Souza1, Tatiana Prata Menezes1, Viviane Gorete Silveira Mouro1, Nayara Magalhães Gonçalves1, Jerusa Maria de Oliveira1, Marc Henry2, Mariana Machado-Neves3.
Abstract
Arsenic impairs male reproductive functions. However, it is not clear whether different arsenic compounds similarly affect fertility. In this study, we compared the impact of sodium arsenite and arsenate on sperm quality and fertility. After 56 d exposure, male Wistar rats were mated and pregnant females were evaluated by fertility indexes. Clearly, exposure to 10 mg/L arsenite reduced daily sperm production via H2O2 overproduction and germ cells loss. Animals from this group also showed a decrease in epididymal sperm counts and percentage of sperm with intact membranes. Moreover, they presented low fertility potential and high preimplantation loss. In contrast, 10 mg/L arsenate caused oxidative stress in testis, mineral imbalance in epididymis, and sperm membranes damage, with no effects on fertility. Both arsenic compounds at 0.01 mg/L altered reproductive parameters. We concluded that arsenite is more harmful than arsenate to sperm quality and male fertility, with negative influences in early pregnancy.Entities:
Keywords: Arsenate; Arsenite; Fertility potential; Reproductive toxicity; Sperm viability; Trace elements imbalance
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Year: 2018 PMID： 29702248 DOI： 10.1016/j.reprotox.2018.04.015
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143