S Strobl1, E J Halpern2, M Abd Ellah1,3, C Kremser1, J Gruber4, R Bellmann-Weiler4, C Deml5, A Schmalzl1, S Rauch1, A S Klauser1. 1. 1 Department of Radiology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. 2. 2 Department of Radiology and Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA. 3. 3 Diagnostic Radiology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt. 4. 4 Department of Internal Medicine II, Medical University Innsbruck, Innsbruck, Austria. 5. 5 Department of Trauma Surgery, Medical University Innsbruck, Innsbruck, Austria.
Abstract
OBJECTIVE: The purpose of this study was to compare findings of ultrasound (US) with dual-energy CT (DECT) findings in patients presenting with suspected gouty knee arthritis. SUBJECTS AND METHODS: This prospective study included 65 patients (52 men and 13 women; median age, 61.7 years [range, 38-87 years]) with an initial clinical diagnosis of acute gouty knee arthritis who underwent DECT performed using a 128-MDCT scanner and US performed using a 5-18-MHz transducer. Both intra- and extraarticular findings obtained using each modality were tabulated. RESULTS: DECT identified gout as the final diagnosis for 52 of 65 patients (80.0%). An alternative diagnosis was confirmed for the remaining 13 patients. US detected gout in 31 of 52 patients (sensitivity, 59.6%) and produced findings negative for gout in seven of 13 patients (specificity, 53.8%). The double contour sign on US was positive for gout in 23 of 52 patients (44.2%) and negative in 12 of 13 patients (92.3%). Extraarticular urate deposition was identified by DECT in 44 of 52 patients, compared with identification by US in 11 of 52 patients (p < 0.001). CONCLUSION: The sensitivity of US for the diagnosis of gouty knee arthritis is limited, particularly with respect to extraarticular urate deposition. The double contour sign is the single most valuable sign for the assessment of gouty knee arthritis by US.
OBJECTIVE: The purpose of this study was to compare findings of ultrasound (US) with dual-energy CT (DECT) findings in patients presenting with suspected gouty knee arthritis. SUBJECTS AND METHODS: This prospective study included 65 patients (52 men and 13 women; median age, 61.7 years [range, 38-87 years]) with an initial clinical diagnosis of acute gouty knee arthritis who underwent DECT performed using a 128-MDCT scanner and US performed using a 5-18-MHz transducer. Both intra- and extraarticular findings obtained using each modality were tabulated. RESULTS: DECT identified gout as the final diagnosis for 52 of 65 patients (80.0%). An alternative diagnosis was confirmed for the remaining 13 patients. US detected gout in 31 of 52 patients (sensitivity, 59.6%) and produced findings negative for gout in seven of 13 patients (specificity, 53.8%). The double contour sign on US was positive for gout in 23 of 52 patients (44.2%) and negative in 12 of 13 patients (92.3%). Extraarticular urate deposition was identified by DECT in 44 of 52 patients, compared with identification by US in 11 of 52 patients (p < 0.001). CONCLUSION: The sensitivity of US for the diagnosis of gouty knee arthritis is limited, particularly with respect to extraarticular urate deposition. The double contour sign is the single most valuable sign for the assessment of gouty knee arthritis by US.
Authors: Andrea S Klauser; Sylvia Strobl; Christoph Schwabl; Werner Klotz; Gudrun Feuchtner; Bernhard Moriggl; Julia Held; Mihra Taljanovic; Jennifer S Weaver; Monique Reijnierse; Elke R Gizewski; Hannes Stofferin Journal: Diagnostics (Basel) Date: 2022-05-16