Rihua Xie1, Haiyan Xie2, Daniel Krewski3, Guoping He4. 1. Department of Nursing, Nanhai Hospital, Southern Medical University, Foshan Guangdong 528244, China; McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa Ontario K1N 6N5, Canada. 2. Department of Aging Industry, Changsha Social Work College, Changsha 410004, China. 3. McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa Ontario K1N 6N5, Canada. 4. Department of Community Nursing, Xiangya School of Nursing, Central South University, Changsha 410013, China.
Abstract
OBJECTIVE: To determine associations between postpartum depression (PPD) and plasma neurotransmitters. Methods: We conducted a case-control study nested to a prospective cohort established in 3 comprehensive tertiary hospitals in Changsha, Hunan, China from February to September 2007. The Chinese version of the Edinburgh Postnatal Depression Scale (EPDS) was used at 2 weeks postpartum to screen PPD, with a score of 13 or higher as the cut-off for PPD. The women with matched age but without PPD and delivery within 5 years were selected as controls. The levels of plasma monoamine neurotransmitters including serotonin (5-hydroxytryptamine, 5-HT), dopamine (DA), and norepinephrine (NE), and peptide neurotransmitters including neuropeptide Y (NPY) and substance P (SP) in maternal blood samples taken at 2 weeks postpartum were measured and compared between PPD women (n=42) and controls (n=42). Results: Plasma levels of 5-HT and NPY were significantly lower while plasma levels of NE and SP were significantly higher in PPD women than those in the controls. For women with PPD, a negative correlation between NPY and NE (r=-0.36, P﹤0.05) was observed. Conclusion: There are changes in plasma levels of neurotransmitters in women with PPD, and there are potential interactions between different neurotransmitters.
OBJECTIVE: To determine associations between postpartum depression (PPD) and plasma neurotransmitters. Methods: We conducted a case-control study nested to a prospective cohort established in 3 comprehensive tertiary hospitals in Changsha, Hunan, China from February to September 2007. The Chinese version of the Edinburgh Postnatal Depression Scale (EPDS) was used at 2 weeks postpartum to screen PPD, with a score of 13 or higher as the cut-off for PPD. The women with matched age but without PPD and delivery within 5 years were selected as controls. The levels of plasma monoamine neurotransmitters including serotonin (5-hydroxytryptamine, 5-HT), dopamine (DA), and norepinephrine (NE), and peptide neurotransmitters including neuropeptide Y (NPY) and substance P (SP) in maternal blood samples taken at 2 weeks postpartum were measured and compared between PPD women (n=42) and controls (n=42). Results: Plasma levels of 5-HT and NPY were significantly lower while plasma levels of NE and SP were significantly higher in PPD women than those in the controls. For women with PPD, a negative correlation between NPY and NE (r=-0.36, P﹤0.05) was observed. Conclusion: There are changes in plasma levels of neurotransmitters in women with PPD, and there are potential interactions between different neurotransmitters.
Authors: Kai Ming Duan; Chao Fang; Si Qi Yang; Shu Ting Yang; Ji Dong Xiao; Huang Chang; Guo Xin Lin; Liang Bin Zhang; Ming Chao Peng; Zhao Qian Liu; Sai Ying Wang Journal: Front Genet Date: 2021-07-07 Impact factor: 4.599
Authors: Fiona A Hagenbeek; Peter J Roetman; René Pool; Cornelis Kluft; Amy C Harms; Jenny van Dongen; Olivier F Colins; Simone Talens; Catharina E M van Beijsterveldt; Marjolein M L J Z Vandenbosch; Eveline L de Zeeuw; Sébastien Déjean; Vassilios Fanos; Erik A Ehli; Gareth E Davies; Jouke Jan Hottenga; Thomas Hankemeier; Meike Bartels; Robert R J M Vermeiren; Dorret I Boomsma Journal: Front Psychiatry Date: 2020-03-31 Impact factor: 4.157