Chiara Pilotto1,2, Eva Passone3, Elisa Coassin4, Silvia Birri5, Ettore Bidoli6, Giovanni Crichiutti3, Paola Cogo7,3, Maurizio Mascarin4. 1. Department of Clinical and Experimental Medical Sciences, DAME, University of Udine, Udine, Italy. pilotto.chiara@spes.uniud.it. 2. Pediatric Clinic, DAME, ASUIUD S. Maria Della Misericordia, University of Udine, Udine, Italy. pilotto.chiara@spes.uniud.it. 3. Pediatric Clinic, DAME, ASUIUD S. Maria Della Misericordia, University of Udine, Udine, Italy. 4. Unit of Pediatric Radiotherapy, Centro di Riferimento Oncologico CRO, Aviano, Italy. 5. Direzione Sanitaria, AAS 5 Friuli Occidentale, Pordenone, Italy. 6. Unit of Cancer Epidemiology, Centro di Riferimento Oncologico CRO, Aviano, Italy. 7. Department of Clinical and Experimental Medical Sciences, DAME, University of Udine, Udine, Italy.
Abstract
PURPOSE: The aim of this study is to compare the prevalence of sleep disorders (SD) between children treated for brain tumors and healthy children, and to define the type of SD. METHODS: A case-control study was performed from October 2014 to April 2015. Inclusion criteria were patients between 2 and 16 years with "cases" defined as children affected by central nervous system tumors at least 3 months after the end of treatment (surgery and/or radiotherapy and/or chemotherapy) at the time of evaluation and "controls" as healthy children. Children's sleep quality was assessed with a questionnaire administered to parents (Child's Sleep Habits Questionnaire, CSHQ). A total score greater than 41 is suggestive for the presence of disturbed sleep. The risk of SD was estimated by the odds ratio (OR) and their 95% confidence intervals (95% CI) through logistic regression models. RESULTS: Twenty-nine cases and 87 controls (in a 1:3 model) were enrolled, for a total of 116 subjects. The prevalence of SD resulted of 82.8% among cases and 64.4% in controls. A statistically significant difference between the two groups (OR 2.65; 95% CI 0.92-7.65) was not reached. Analyzing singular disturbances, parasomnias and night awakenings showed a statistically significant difference between the two groups (OR 4.32; 95% CI 1.08-17.34). CONCLUSIONS: Our study revealed a trend toward SD in children with brain tumor when compared to healthy population. Hovewer, analyzing specific subtypes of SD some significant differences were obtained. A significant difference was obtained only for specific subtypes of SD. Further investigations could better define the real burden of SD.
PURPOSE: The aim of this study is to compare the prevalence of sleep disorders (SD) between children treated for brain tumors and healthy children, and to define the type of SD. METHODS: A case-control study was performed from October 2014 to April 2015. Inclusion criteria were patients between 2 and 16 years with "cases" defined as children affected by central nervous system tumors at least 3 months after the end of treatment (surgery and/or radiotherapy and/or chemotherapy) at the time of evaluation and "controls" as healthy children. Children's sleep quality was assessed with a questionnaire administered to parents (Child's Sleep Habits Questionnaire, CSHQ). A total score greater than 41 is suggestive for the presence of disturbed sleep. The risk of SD was estimated by the odds ratio (OR) and their 95% confidence intervals (95% CI) through logistic regression models. RESULTS: Twenty-nine cases and 87 controls (in a 1:3 model) were enrolled, for a total of 116 subjects. The prevalence of SD resulted of 82.8% among cases and 64.4% in controls. A statistically significant difference between the two groups (OR 2.65; 95% CI 0.92-7.65) was not reached. Analyzing singular disturbances, parasomnias and night awakenings showed a statistically significant difference between the two groups (OR 4.32; 95% CI 1.08-17.34). CONCLUSIONS: Our study revealed a trend toward SD in children with brain tumor when compared to healthy population. Hovewer, analyzing specific subtypes of SD some significant differences were obtained. A significant difference was obtained only for specific subtypes of SD. Further investigations could better define the real burden of SD.
Authors: Beth L Goodlin-Jones; Stephanie L Sitnick; Karen Tang; Jingyi Liu; Thomas F Anders Journal: J Dev Behav Pediatr Date: 2008-04 Impact factor: 2.225
Authors: Ineke M Olsthoorn; Alice Ann Holland; Raymond C Hawkins; Allen E Cornelius; Muhammad Usman Baig; Grace Yang; Daniel C Holland; Wafik Zaky; Peter L Stavinoha Journal: Front Neurosci Date: 2022-06-23 Impact factor: 5.152