Literature DB >> 29700168

Phase I study of the heparanase inhibitor roneparstat: an innovative approach for ultiple myeloma therapy.

Monica Galli1, Manik Chatterjee2, Mariella Grasso3, Giorgina Specchia4, Hila Magen5, Hermann Einsele2, Ivana Celeghini3, Paola Barbieri6, David Paoletti6, Silvia Pace7, Ralph D Sanderson8, Alessandro Rambaldi9,10, Arnon Nagler5.   

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Year:  2018        PMID： 29700168      PMCID： PMC6165822          DOI： 10.3324/haematol.2017.182865

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  13 in total

1.  Heparanase as a target in cancer therapy.

Authors:  Valentina Masola; Maria Francesca Secchi; Giovanni Gambaro; Maurizio Onisto
Journal:  Curr Cancer Drug Targets       Date:  2014       Impact factor: 3.428

2.  Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.

Authors:  Vishnu C Ramani; Israel Vlodavsky; Mary Ng; Yi Zhang; Paola Barbieri; Alessandro Noseda; Ralph D Sanderson
Journal:  Matrix Biol       Date:  2016-03-22       Impact factor: 11.583

Review 3.  Heparanase: From basic research to therapeutic applications in cancer and inflammation.

Authors:  Israel Vlodavsky; Preeti Singh; Ilanit Boyango; Lilach Gutter-Kapon; Michael Elkin; Ralph D Sanderson; Neta Ilan
Journal:  Drug Resist Updat       Date:  2016-10-06       Impact factor: 18.500

Review 4.  Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.

Authors:  Ralph D Sanderson; Michael Elkin; Alan C Rapraeger; Neta Ilan; Israel Vlodavsky
Journal:  FEBS J       Date:  2016-11-16       Impact factor: 5.542

5.  Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.

Authors:  Anurag Purushothaman; Ligong Chen; Yang Yang; Ralph D Sanderson
Journal:  J Biol Chem       Date:  2008-09-23       Impact factor: 5.157

6.  Soluble syndecan-1 promotes growth of myeloma tumors in vivo.

Authors:  Yang Yang; Shmuel Yaccoby; Wei Liu; J Kevin Langford; Carla Y Pumphrey; Allison Theus; Joshua Epstein; Ralph D Sanderson
Journal:  Blood       Date:  2002-07-15       Impact factor: 22.113

7.  High heparanase activity in multiple myeloma is associated with elevated microvessel density.

Authors:  Thomas Kelly; Hua-Quan Miao; Yang Yang; Elizabeth Navarro; Paul Kussie; Yan Huang; Veronica MacLeod; Jonathan Casciano; Lija Joseph; Fenghuang Zhan; Maurizio Zangari; Bart Barlogie; John Shaughnessy; Ralph D Sanderson
Journal:  Cancer Res       Date:  2003-12-15       Impact factor: 12.701

8.  Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.

Authors:  Yang Yang; Veronica Macleod; Hua-Quan Miao; Allison Theus; Fenghuang Zhan; John D Shaughnessy; Jeffrey Sawyer; Jin-Ping Li; Eyal Zcharia; Israel Vlodavsky; Ralph D Sanderson
Journal:  J Biol Chem       Date:  2007-03-08       Impact factor: 5.157

9.  Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma.

Authors:  Vishnu C Ramani; Fenghuang Zhan; Jianbo He; Paola Barbieri; Alessandro Noseda; Guido Tricot; Ralph D Sanderson
Journal:  Oncotarget       Date:  2016-01-12

10.  Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.

Authors:  Daniele Pala; Silvia Rivara; Marco Mor; Ferdinando Maria Milazzo; Giuseppe Roscilli; Emiliano Pavoni; Giuseppe Giannini
Journal:  Glycobiology       Date:  2016-01-13       Impact factor: 4.313
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  22 in total

Review 1.  Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options.

Authors:  Chaoying Qin; Meng Huang; Yimin Pan; Yuzhe Li; Wenyong Long; Qing Liu
Journal:  Brain Tumor Pathol       Date:  2021-04-26       Impact factor: 3.298

2.  Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3.

Authors:  Ibrahim Knani; Preeti Singh; Miriam Gross-Cohen; Sharon Aviram; Neta Ilan; Ralph D Sanderson; Ami Aronheim; Israel Vlodavsky
Journal:  Matrix Biol       Date:  2021-11-20       Impact factor: 11.583

3.  Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19.

Authors:  Jingyu Xiang; Mijia Lu; Min Shi; Xiaogang Cheng; Kristin A Kwakwa; Jennifer L Davis; Xinming Su; Suzanne J Bakewell; Yuexiu Zhang; Francesca Fontana; Yalin Xu; Deborah J Veis; John F DiPersio; Lee Ratner; Ralph D Sanderson; Alessandro Noseda; Shamim Mollah; Jianrong Li; Katherine N Weilbaecher
Journal:  J Virol       Date:  2022-03-23       Impact factor: 5.103

4.  Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury.

Authors:  Valentina Masola; Gloria Bellin; Gisella Vischini; Luigi Dall'Olmo; Simona Granata; Giovanni Gambaro; Antonio Lupo; Maurizio Onisto; Gianluigi Zaza
Journal:  Oncotarget       Date:  2018-11-16

Review 5.  Multiple Roles of Glycans in Hematological Malignancies.

Authors:  Xingchen Pang; Hongjiao Li; Feng Guan; Xiang Li
Journal:  Front Oncol       Date:  2018-09-06       Impact factor: 6.244

Review 6.  Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity.

Authors:  Cinzia Lanzi; Giuliana Cassinelli
Journal:  Molecules       Date:  2018-11-08       Impact factor: 4.411

Review 7.  Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.

Authors:  Verena Petzer; Igor Theurl; Günter Weiss
Journal:  Pharmaceuticals (Basel)       Date:  2018-12-11

8.  Serum heparanase levels and left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.

Authors:  Mehmet Fatih Yilmaz; Emrah Acar; Mehmet Inanir; Can Yücel Karabay; Ibrahim Akin Izgi
Journal:  Herz       Date:  2021-08-05       Impact factor: 1.443

Review 9.  Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer.

Authors:  Simone Furini; Chiara Falciani
Journal:  Front Oncol       Date:  2021-06-25       Impact factor: 6.244

Review 10.  Clinical applications of exosome membrane proteins.

Authors:  Qian Hu; Hang Su; Juan Li; Christopher Lyon; Wenfu Tang; Meihua Wan; Tony Ye Hu
Journal:  Precis Clin Med       Date:  2020-02-24
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