Literature DB >> 29700066

Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation.

Dan M Roden1,2,3, Sara L Van Driest4,5, Quinn S Wells4,2, Jonathan D Mosley4, Joshua C Denny4,3, Josh F Peterson4,3.   

Abstract

This review will provide an overview of the principles of pharmacogenomics from basic discovery to implementation, encompassing application of tools of contemporary genome science to the field (including areas of apparent divergence from disease-based genomics), a summary of lessons learned from the extensively studied drugs clopidogrel and warfarin, the current status of implementing pharmacogenetic testing in practice, the role of genomics and related tools in the drug development process, and a summary of future opportunities and challenges.
© 2018 American Heart Association, Inc.

Entities:  

Keywords:  clopidogrel; genomics; pharmacogenetics; pharmacokinetics; warfarin

Mesh：

Substances：

Year:  2018        PMID： 29700066      PMCID： PMC5926807          DOI： 10.1161/CIRCRESAHA.117.310965

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  137 in total

1.  PharmGKB summary: very important pharmacogene information for CYP3A5.

Authors:  Jatinder Lamba; Joan M Hebert; Erin G Schuetz; Teri E Klein; Russ B Altman
Journal:  Pharmacogenet Genomics       Date:  2012-07       Impact factor: 2.089

2.  Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

Authors:  Babar Parvez; Joseph Vaglio; Shane Rowan; Raafia Muhammad; Gayle Kucera; Tanya Stubblefield; Shannon Carter; Dan Roden; Dawood Darbar
Journal:  J Am Coll Cardiol       Date:  2012-06-20       Impact factor: 24.094

3.  Codeine, ultrarapid-metabolism genotype, and postoperative death.

Authors:  Catherine Ciszkowski; Parvaz Madadi; Michael S Phillips; Albert E Lauwers; Gideon Koren
Journal:  N Engl J Med       Date:  2009-08-20       Impact factor: 91.245

4.  Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.

Authors:  L R Brunham; P J Lansberg; L Zhang; F Miao; C Carter; G K Hovingh; H Visscher; J W Jukema; A F Stalenhoef; C J D Ross; B C Carleton; J J P Kastelein; M R Hayden
Journal:  Pharmacogenomics J       Date:  2011-01-18       Impact factor: 3.550

Review 5.  Global implementation of genomic medicine: We are not alone.

Authors:  Teri A Manolio; Marc Abramowicz; Fahd Al-Mulla; Warwick Anderson; Rudi Balling; Adam C Berger; Steven Bleyl; Aravinda Chakravarti; Wasun Chantratita; Rex L Chisholm; Vajira H W Dissanayake; Michael Dunn; Victor J Dzau; Bok-Ghee Han; Tim Hubbard; Anne Kolbe; Bruce Korf; Michiaki Kubo; Paul Lasko; Erkki Leego; Surakameth Mahasirimongkol; Partha P Majumdar; Gert Matthijs; Howard L McLeod; Andres Metspalu; Pierre Meulien; Satoru Miyano; Yaakov Naparstek; P Pearl O'Rourke; George P Patrinos; Heidi L Rehm; Mary V Relling; Gad Rennert; Laura Lyman Rodriguez; Dan M Roden; Alan R Shuldiner; Sukdeb Sinha; Patrick Tan; Mats Ulfendahl; Robyn Ward; Marc S Williams; John E L Wong; Eric D Green; Geoffrey S Ginsburg
Journal:  Sci Transl Med       Date:  2015-06-03       Impact factor: 17.956

6.  Hereditary aspects of malignant hyperthermia.

Authors:  B A Britt; W G Locher; W Kalow
Journal:  Can Anaesth Soc J       Date:  1969-03

7.  A pharmacogenetic versus a clinical algorithm for warfarin dosing.

Authors:  Stephen E Kimmel; Benjamin French; Scott E Kasner; Julie A Johnson; Jeffrey L Anderson; Brian F Gage; Yves D Rosenberg; Charles S Eby; Rosemary A Madigan; Robert B McBane; Sherif Z Abdel-Rahman; Scott M Stevens; Steven Yale; Emile R Mohler; Margaret C Fang; Vinay Shah; Richard B Horenstein; Nita A Limdi; James A S Muldowney; Jaspal Gujral; Patrice Delafontaine; Robert J Desnick; Thomas L Ortel; Henny H Billett; Robert C Pendleton; Nancy L Geller; Jonathan L Halperin; Samuel Z Goldhaber; Michael D Caldwell; Robert M Califf; Jonas H Ellenberg
Journal:  N Engl J Med       Date:  2013-11-19       Impact factor: 91.245

8.  Clopidogrel: a case for indication-specific pharmacogenetics.

Authors:  J A Johnson; D M Roden; L J Lesko; E Ashley; T E Klein; A R Shuldiner
Journal:  Clin Pharmacol Ther       Date:  2012-05       Impact factor: 6.875

Review 9.  Genome-wide association studies in pharmacogenomics: successes and lessons.

Authors:  Alison A Motsinger-Reif; Eric Jorgenson; Mary V Relling; Deanna L Kroetz; Richard Weinshilboum; Nancy J Cox; Dan M Roden
Journal:  Pharmacogenet Genomics       Date:  2013-08       Impact factor: 2.089

Review 10.  The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.

Authors:  L H Cavallari; A L Beitelshees; K V Blake; L G Dressler; J D Duarte; A Elsey; J N Eichmeyer; P E Empey; J P Franciosi; J K Hicks; A M Holmes; Ljb Jeng; C R Lee; J J Lima; N A Limdi; J Modlin; A O Obeng; N Petry; V M Pratt; T C Skaar; S Tuteja; D Voora; M Wagner; K W Weitzel; R A Wilke; J F Peterson; J A Johnson
Journal:  Clin Transl Sci       Date:  2017-03-14       Impact factor: 4.689
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  13 in total

1.  Omics, Big Data, and Precision Medicine in Cardiovascular Sciences.

Authors:  Edward Lau; Joseph C Wu
Journal:  Circ Res       Date:  2018-04-27       Impact factor: 17.367

Review 2.  Pharmacogenomics of chronic obstructive pulmonary disease.

Authors:  Craig P Hersh
Journal:  Expert Rev Respir Med       Date:  2019-04-08       Impact factor: 3.772

Review 3.  The promise and reality of therapeutic discovery from large cohorts.

Authors:  Eugene Melamud; D Leland Taylor; Anurag Sethi; Madeleine Cule; Anastasia Baryshnikova; Danish Saleheen; Nick van Bruggen; Garret A FitzGerald
Journal:  J Clin Invest       Date:  2020-02-03       Impact factor: 14.808

Review 4.  The Propagation of Racial Disparities in Cardiovascular Genomics Research.

Authors:  Shoa L Clarke; Themistocles L Assimes; Catherine Tcheandjieu
Journal:  Circ Genom Precis Med       Date:  2021-08-31

Review 5.  Pharmacogenomics in dermatology: tools for understanding gene-drug associations.

Authors:  Roxana Daneshjou; Rachel Huddart; Teri E Klein; Russ B Altman
Journal:  Semin Cutan Med Surg       Date:  2019-03-01

6.  Growing Pains in Cardiovascular Genetics.

Authors:  Dan M Roden
Journal:  Circulation       Date:  2018-09-18       Impact factor: 29.690

Review 7.  Perspectives in Individualizing Solutions for Dialysis Access.

Authors:  Silvi Shah; Micah R Chan; Timmy Lee
Journal:  Adv Chronic Kidney Dis       Date:  2020-05       Impact factor: 3.620

Review 8.  Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions.

Authors:  Ramón Cacabelos; Vinogran Naidoo; Lola Corzo; Natalia Cacabelos; Juan C Carril
Journal:  Int J Mol Sci       Date:  2021-12-10       Impact factor: 5.923

Review 9.  Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients.

Authors:  Thiago Dominguez Crespo Hirata; Carolina Dagli-Hernandez; Fabiana Dalla Vecchia Genvigir; Volker Martin Lauschke; Yitian Zhou; Mario Hiroyuki Hirata; Rosario Dominguez Crespo Hirata
Journal:  Mol Diagn Ther       Date:  2021-08-06       Impact factor: 4.074

10.  Pharmacogenomics in Cardiovascular Diseases.

Authors:  Caitrin W McDonough
Journal:  Curr Protoc       Date:  2021-07
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