Viktor A Reva1, Yosuke Matsumura2, Igor M Samokhvalov3, Alexander A Pochtarnik3, Igor S Zheleznyak4, Ekaterina M Mikhailovskaya4, Jonathan J Morrison5. 1. Department of War Surgery, Kirov Military Medical Academy, 6 Lebedeva Street, Saint-Petersburg 194044, Russian Federation. Electronic address: vreva@mail.ru. 2. Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan. 3. Department of War Surgery, Kirov Military Medical Academy, 6 Lebedeva Street, Saint-Petersburg 194044, Russian Federation. 4. Department of Radiology, Kirov Military Medical Academy, 6 Lebedeva Street, Saint-Petersburg 194044, Russian Federation. 5. R. Adams Cowley Shock Trauma Center, University of Maryland Medical System, 22 S Greene St., Baltimore, MD 21201, USA.
Abstract
INTRODUCTION: Partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA) is a modified REBOA technique designed to help ameliorate ischemia-reperfusion injury. The balloon is partially deflated, allowing a proportion of aortic flow distal to the balloon. The aim of this study is to use an ovine model of haemorrhagic shock to correlate the degree of occlusion to several hemodynamic indices. MATERIALS AND METHODS: Six sheep weighing 35-46 kg underwent a controlled venous haemorrhage inside a CT scanner until the systolic arterial pressure (AP) dropped to <90 mmHg. A balloon positioned in an aortic zone I was incrementally filled with 1 mL of saline, with serial measurement of the proximal (carotid artery) and distal (femoral artery) mean APs (MAP) and intra-balloon pressure (IBP), along with CT imaging, following each inflation, until full occlusion was achieved. RESULTS: A diameter of the aorta at zone I was 16.0 (15.7-17.2) mm, with a cross-sectional area of 212 (194-233) mm2. Median volume of saline injected into the balloon until total occlusion was 7.0 (6.3-8.5) mL. During gradual balloon inflation, proximal MAP increased and distal MAP decreased proportionate to the degree of occlusion, in a linear fashion (proximal: r2 = 0.85, p < 0.001; distal: r2 = 0.95, p < 0.001). The femoral/carotid (F/C) pressure gradient also demonstrated a linear trend (r2 = 0.90, p < 0.001). The relationship between percentage occlusion and IBP was sigmoid. MAP values became significantly different at 40-49% occlusion and more (p < 0.01). Furthermore, a drop in the distal pulse pressure from 7.0 (5.5-16.5) to 2.0 (1.5-5.0) mmHg was observed at 80% occlusion. All animals had femoral pulse pressure <5 mmHg at 80% of occlusion and more, which also coincided with the observed loss of pulsatility of the femoral wave-form. CONCLUSION: Serial CT angiography at an ovine model of haemorrhagic shock demonstrates a correlation between the femoral MAP, F/C pressure gradient and degree of zone I P-REBOA during the staged partial aortic occlusion. These parameters should be considered potential parameters to define the degree of P-REBOA during animal research and clinical practice.
INTRODUCTION: Partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA) is a modified REBOA technique designed to help ameliorate ischemia-reperfusion injury. The balloon is partially deflated, allowing a proportion of aortic flow distal to the balloon. The aim of this study is to use an ovine model of haemorrhagic shock to correlate the degree of occlusion to several hemodynamic indices. MATERIALS AND METHODS: Six sheep weighing 35-46 kg underwent a controlled venous haemorrhage inside a CT scanner until the systolic arterial pressure (AP) dropped to <90 mmHg. A balloon positioned in an aortic zone I was incrementally filled with 1 mL of saline, with serial measurement of the proximal (carotid artery) and distal (femoral artery) mean APs (MAP) and intra-balloon pressure (IBP), along with CT imaging, following each inflation, until full occlusion was achieved. RESULTS: A diameter of the aorta at zone I was 16.0 (15.7-17.2) mm, with a cross-sectional area of 212 (194-233) mm2. Median volume of saline injected into the balloon until total occlusion was 7.0 (6.3-8.5) mL. During gradual balloon inflation, proximal MAP increased and distal MAP decreased proportionate to the degree of occlusion, in a linear fashion (proximal: r2 = 0.85, p < 0.001; distal: r2 = 0.95, p < 0.001). The femoral/carotid (F/C) pressure gradient also demonstrated a linear trend (r2 = 0.90, p < 0.001). The relationship between percentage occlusion and IBP was sigmoid. MAP values became significantly different at 40-49% occlusion and more (p < 0.01). Furthermore, a drop in the distal pulse pressure from 7.0 (5.5-16.5) to 2.0 (1.5-5.0) mmHg was observed at 80% occlusion. All animals had femoral pulse pressure <5 mmHg at 80% of occlusion and more, which also coincided with the observed loss of pulsatility of the femoral wave-form. CONCLUSION: Serial CT angiography at an ovine model of haemorrhagic shock demonstrates a correlation between the femoral MAP, F/C pressure gradient and degree of zone I P-REBOA during the staged partial aortic occlusion. These parameters should be considered potential parameters to define the degree of P-REBOA during animal research and clinical practice.
Authors: Adenauer Marinho de Oliveira Góes; Rosa Helena de Figueiredo Chaves; Ismari Perini Furlaneto; Emanuelle de Matos Rodrigues; Flávia Beatriz Araújo de Albuquerque; Jacob Hindrik Antunes Smit; Carolina Pinheiro de Oliveira; Simone de Campos Vieira Abib Journal: J Vasc Bras Date: 2021-05-14