Misao Terada1,2, Mark Oláh2, György M Nagy2, Kazumi Taniguchi3, Fumio Sato4, Shiro Muranaka5, Wirasak Fungfuang5, Pudcharaporn Kromkhun5,6, Tomoaki Nakada5, Makoto Yokosuka5, Toru R Saito5. 1. Division of Laboratory Animal Science Nippon Medical School Bunkyo Tokyo Japan. 2. Neuroendocrine Research Laboratory, Department of Human Morphology Hungarian Academy of Science and Semmelweis University Budapest Hungary. 3. Department of Veterinary Anatomy Kitasato University Towada Aomori Japan. 4. Hidaka Training and Research Center Japan Racing Association Urakawa Hokkaido Japan. 5. Behavioral Neuroscience Laboratory, Veterinary Medicine Nippon Veterinary and Life Science University 1-7-1 Kyonan-cho 180-8602 Musashino Tokyo Japan. 6. Department of Physiology Kasetsart University Bangkok Thailand.
Abstract
PURPOSE: The dopamine-derived endogenous compound, R-salsolinol (SAL), was recently identified as a putative endogenous prolactin (PRL)-releasing factor. However, how SAL influences copulatory behavior is unknown. In this study, we examined the relationship between SAL and copulatory behavior in male rats. METHODS: Male Sprague-Dawley rats administered SAL were exposed to female rats in estrus, the plasma PRL concentration was measured, and the behavioral frequency and time during copulatory behavior were noted. RESULTS: In the control and SAL groups, plasma PRL concentrations at 15 min before exposure to the female were 7.3 ± 2.0 and 8.0 ± 1.5 ng/ml, respectively. Moreover, plasma PRL concentrations in males immediately after exposure to the female were 7.4 ± 1.2 and 68.0 ± 5.9 ng/ml, respectively (P < 0.05). All (8/8) of the control animals ejaculated in the presence of the female, whereas only 33% (2/6) of the SAL group ejaculated. An increasing tendency for mount latency and intromission latency and a decreasing tendency for intromission frequency were observed in the SAL group. CONCLUSIONS: Copulatory behavior was inhibited in male rats after SAL injection, suggesting that SAL is a copulatory behavior inhibiting factor.
PURPOSE: The dopamine-derived endogenous compound, R-salsolinol (SAL), was recently identified as a putative endogenous prolactin (PRL)-releasing factor. However, how SAL influences copulatory behavior is unknown. In this study, we examined the relationship between SAL and copulatory behavior in male rats. METHODS: Male Sprague-Dawley rats administered SAL were exposed to female rats in estrus, the plasma PRL concentration was measured, and the behavioral frequency and time during copulatory behavior were noted. RESULTS: In the control and SAL groups, plasma PRL concentrations at 15 min before exposure to the female were 7.3 ± 2.0 and 8.0 ± 1.5 ng/ml, respectively. Moreover, plasma PRL concentrations in males immediately after exposure to the female were 7.4 ± 1.2 and 68.0 ± 5.9 ng/ml, respectively (P < 0.05). All (8/8) of the control animals ejaculated in the presence of the female, whereas only 33% (2/6) of the SAL group ejaculated. An increasing tendency for mount latency and intromission latency and a decreasing tendency for intromission frequency were observed in the SAL group. CONCLUSIONS: Copulatory behavior was inhibited in male rats after SAL injection, suggesting that SAL is a copulatory behavior inhibiting factor.
Entities:
Keywords:
Copulatory behavior; Hyperprolactinemia; Male rat; Prolactin‐releasing factor; Salsolinol
Authors: B E Tóth; K Homicskó; B Radnai; W Maruyama; J E DeMaria; M Vecsernyés; M I Fekete; F Fülöp; M Naoi; M E Freeman; G M Nagy Journal: J Neuroendocrinol Date: 2001-12 Impact factor: 3.627
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