Seiichi Yoshida1, Kyoko Hiyoshi1, Takamichi Ichinose1, Masataka Nishikawa2, Hirohisa Takano3, Isamu Sugawara4, Ken Takeda5. 1. Department of Health Sciences Oita University of Nursing and Health Sciences 2944-9 Megusuno 870-1201 Oita Oita Japan. 2. Environmental Chemistry Division National Institute for Environmental Studies 16-2 Onogawa 305-0053 Tsukuba Ibaraki Japan. 3. Pathophysiology Research National Institute for Environmental Studies 16-2 Onogawa 305-0053 Tsukuba Ibaraki Japan. 4. Mycobacterium Reference Center Research Institute of Tuberculosis 3-1-24 Matsuyama 204-8533 Kiyose Tokyo Japan. 5. Faculty of Pharmaceutical Sciences Tokyo University of Science 2641 Yamazaki 278-8510 Noda Chiba Japan.
Abstract
PURPOSE: Although adverse health effects of environment (such as cadmium, pesticides, diesel exhaust, etc.) on the male reproductive system have been suggested, there is little experimental evidence of such an effect of atmospheric sand dust. In the present study, the effects of sand dust (mineral particles) were investigated on the male reproductive system of mice. METHODS: Two types of sand dusts (Asian sand dust and Arizona sand dust) were intratracheally administered (0.1 mg/mouse 4 times every other week) to ICR male mice and then male reproductive organ weight, daily sperm production (DSP), histological analysis and serum testosterone level were measured. RESULTS: Histological examination showed that interstitial edema was produced by both sand dust types, and partial vacuolation of the seminiferous tubules was detected in the exposed mice. Moreover, exposure to these natural sand dusts significantly decreased DSP. On the other hand, there was no significant differences in serum testosterone concentration. CONCLUSIONS: These results suggest that natural sand dust-exposure produced adverse effects on mouse male reproductive function.
PURPOSE: Although adverse health effects of environment (such as cadmium, pesticides, diesel exhaust, etc.) on the male reproductive system have been suggested, there is little experimental evidence of such an effect of atmospheric sand dust. In the present study, the effects of sand dust (mineral particles) were investigated on the male reproductive system of mice. METHODS: Two types of sand dusts (Asian sand dust and Arizona sand dust) were intratracheally administered (0.1 mg/mouse 4 times every other week) to ICR male mice and then male reproductive organ weight, daily sperm production (DSP), histological analysis and serum testosterone level were measured. RESULTS: Histological examination showed that interstitial edema was produced by both sand dust types, and partial vacuolation of the seminiferous tubules was detected in the exposed mice. Moreover, exposure to these natural sand dusts significantly decreased DSP. On the other hand, there was no significant differences in serum testosterone concentration. CONCLUSIONS: These results suggest that natural sand dust-exposure produced adverse effects on mouse male reproductive function.
Entities:
Keywords:
Daily sperm production; Intratracheal instillation; Male reproduction; Mineral particles; Sand dust
Authors: Lorraine Craig; Jeffrey R Brook; Quentin Chiotti; Bart Croes; Stephanie Gower; Anthony Hedley; Daniel Krewski; Alan Krupnick; Michal Krzyzanowski; Michael D Moran; William Pennell; Jonathan M Samet; Jurgen Schneider; John Shortreed; Martin Williams Journal: J Toxicol Environ Health A Date: 2008
Authors: T Ichinose; S Yoshida; K Hiyoshi; K Sadakane; H Takano; M Nishikawa; I Mori; R Yanagisawa; H Kawazato; A Yasuda; T Shibamoto Journal: Arch Environ Contam Toxicol Date: 2008-01-29 Impact factor: 2.804