| Literature DB >> 29699096 |
Abstract
Despite its structural simplicity, hyaluronan exhibits a broad spectrum of biological activities. Cumulus expansion observed during oocyte maturation in mammals is also induced by hyaluronan accumulation in cumulus-oocyte complexes. It has been demonstrated that this volumetric change in cumulus-oocyte complexes correlates with the progression of oocyte maturation. We have investigated the molecular mechanism of oocyte maturation in mammals, focusing on hyaluronan accumulation in cumulus-oocyte complexes during cumulus expansion. In this review, we describe the physiological function of hyaluronan, emphasizing the progression of oocyte maturation in mammals based on our previous findings.Entities:
Keywords: CD44; Cumulus expansion; Hyaluronan; Meiotic resumption; Oocyte
Year: 2011 PMID: 29699096 PMCID: PMC5904653 DOI: 10.1007/s12522-011-0093-6
Source DB: PubMed Journal: Reprod Med Biol ISSN: 1445-5781