Nobumasa Kikuchi1, Kazumichi Andoh1, Hideki Mizunuma2, Takashi Minegishi1. 1. Department of Obstetrics and Gynecology, Gunma University School of Medicine, Gunma and. 2. Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Japan.
Abstract
Aim: To clarify the role of leptin in women with polycystic ovary syndrome (PCOS), we analyzed whether serum leptin levels correlate with other hormonal parameters in obese and non-obese women with PCOS. Methods: We studied 20 obese (body mass index, BM ≥25 kg/m2) and 20 non-obese (BMI <25 kg/m2) women with PCOS diagnosed by the existence of menstrual disturbance, elevated serum level of luteinizing hormone (LH) with normal follicle-stimulating hormone (FSH) and the characteristic polycystic appearance of the ovaries on transvaginal ultrasound images. Blood samples for LH, FSH, estradiol, testosterone (T), androstenedione (Δ4) and leptin were obtained, and the relationships between variables were examined by calculating Spearman correlation coefficients. Results: Mean levels of leptin, T and Δ4 in obese PCOS women were significantly higher than those in non-obese PCOS women, but this was not the case for BMI, bodyweight and waist to hip ratio. In all the 40 PCOS women considered together, there were significant positive correlations of leptin with BMI, waist to hip ratio, and Δ4 levels. However, in each group separately, serum leptin levels in obese PCOS women correlated only with BMI and bodyweight, whereas serum leptin levels in non-obese PCOS women correlated with serum A4 levels. Conclusion: Although further study is needed to assess the role of leptin on ovarian function in non-obese women with PCOS, present findings do not support the fact that leptin is involved in the development of hormonal abnormalities in obese women with PCOS. (Reprod Med Biol 2002; 1: 49-54).
Aim: To clarify the role of leptin in women with polycystic ovary syndrome (PCOS), we analyzed whether serum leptin levels correlate with other hormonal parameters in obese and non-obesewomen with PCOS. Methods: We studied 20 obese (body mass index, BM ≥25 kg/m2) and 20 non-obese (BMI <25 kg/m2) women with PCOS diagnosed by the existence of menstrual disturbance, elevated serum level of luteinizing hormone (LH) with normal follicle-stimulating hormone (FSH) and the characteristic polycystic appearance of the ovaries on transvaginal ultrasound images. Blood samples for LH, FSH, estradiol, testosterone (T), androstenedione (Δ4) and leptin were obtained, and the relationships between variables were examined by calculating Spearman correlation coefficients. Results: Mean levels of leptin, T and Δ4 in obese PCOSwomen were significantly higher than those in non-obese PCOSwomen, but this was not the case for BMI, bodyweight and waist to hip ratio. In all the 40 PCOSwomen considered together, there were significant positive correlations of leptin with BMI, waist to hip ratio, and Δ4 levels. However, in each group separately, serum leptin levels in obese PCOSwomen correlated only with BMI and bodyweight, whereas serum leptin levels in non-obese PCOSwomen correlated with serum A4 levels. Conclusion: Although further study is needed to assess the role of leptin on ovarian function in non-obesewomen with PCOS, present findings do not support the fact that leptin is involved in the development of hormonal abnormalities in obesewomen with PCOS. (Reprod Med Biol 2002; 1: 49-54).
Authors: D Micić; D Macut; V Popović; M Sumarac-Dumanović; A Kendereski; M Colić; C Dieguez; F F Casanueva Journal: Gynecol Endocrinol Date: 1997-10 Impact factor: 2.260
Authors: R V Considine; M K Sinha; M L Heiman; A Kriauciunas; T W Stephens; M R Nyce; J P Ohannesian; C C Marco; L J McKee; T L Bauer Journal: N Engl J Med Date: 1996-02-01 Impact factor: 91.245
Authors: J L Halaas; K S Gajiwala; M Maffei; S L Cohen; B T Chait; D Rabinowitz; R L Lallone; S K Burley; J M Friedman Journal: Science Date: 1995-07-28 Impact factor: 47.728