Literature DB >> 29698722

Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility.

Jamaji C Nwanaji-Enwerem1, Marc G Weisskopf2, Andrea A Baccarelli3.   

Abstract

The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. In this review, we discuss the existing literature regarding DNAm-age's molecular relationships in six major categories: animal model systems, cancer processes, cellular aging processes, immune system processes, metabolic processes, and nucleic acid processes. We also present perspectives regarding the future of DNAm-age research, including the need to translate a greater number of ongoing research efforts to experimental and animal model systems.
Copyright © 2018 Elsevier B.V. All rights reserved.

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Year:  2018        PMID： 29698722      PMCID： PMC6047923          DOI： 10.1016/j.arr.2018.04.005

Source DB:  PubMed          Journal:  Ageing Res Rev        ISSN： 1568-1637            Impact factor:   11.788


  69 in total

1.  Investigation of correlations between DNA methylation, suicidal behavior and aging.

Authors:  Richie Jeremian; Yi-An Chen; Vincenzo De Luca; John B Vincent; James L Kennedy; Clement C Zai; John Strauss
Journal:  Bipolar Disord       Date:  2017-03-09       Impact factor: 6.744

2.  Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders.

Authors:  Andrew J Levine; Austin Quach; David J Moore; Cristian L Achim; Virawudh Soontornniyomkij; Eliezer Masliah; Elyse J Singer; Benjamin Gelman; Natasha Nemanim; Steve Horvath
Journal:  J Neurovirol       Date:  2015-12-21       Impact factor: 2.643

3.  Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients.

Authors:  Steve Horvath; Beate R Ritz
Journal:  Aging (Albany NY)       Date:  2015-12       Impact factor: 5.682

4.  HIV-1 Infection Accelerates Age According to the Epigenetic Clock.

Authors:  Steve Horvath; Andrew J Levine
Journal:  J Infect Dis       Date:  2015-05-12       Impact factor: 5.226

5.  Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.

Authors:  Steve Horvath; Peter Langfelder; Seung Kwak; Jeff Aaronson; Jim Rosinski; Thomas F Vogt; Marika Eszes; Richard L M Faull; Maurice A Curtis; Henry J Waldvogel; Oi-Wa Choi; Spencer Tung; Harry V Vinters; Giovanni Coppola; X William Yang
Journal:  Aging (Albany NY)       Date:  2016-07       Impact factor: 5.682

6.  Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals.

Authors:  Tapio Nevalainen; Laura Kananen; Saara Marttila; Juulia Jylhävä; Nina Mononen; Mika Kähönen; Olli T Raitakari; Antti Hervonen; Marja Jylhä; Terho Lehtimäki; Mikko Hurme
Journal:  Clin Epigenetics       Date:  2017-02-14       Impact factor: 6.551

7.  DNA methylation age of human tissues and cell types.

Authors:  Steve Horvath
Journal:  Genome Biol       Date:  2013       Impact factor: 13.583

8.  The epigenetic clock and telomere length are independently associated with chronological age and mortality.

Authors:  Riccardo E Marioni; Sarah E Harris; Sonia Shah; Allan F McRae; Thomas von Zglinicki; Carmen Martin-Ruiz; Naomi R Wray; Peter M Visscher; Ian J Deary
Journal:  Int J Epidemiol       Date:  2016-04-13       Impact factor: 7.196

9.  Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.

Authors:  Ake T Lu; Eilis Hannon; Morgan E Levine; Eileen M Crimmins; Katie Lunnon; Jonathan Mill; Daniel H Geschwind; Steve Horvath
Journal:  Nat Commun       Date:  2017-05-18       Impact factor: 14.919

10.  Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults.

Authors:  Xu Gao; Yan Zhang; Hermann Brenner
Journal:  Br J Cancer       Date:  2017-09-12       Impact factor: 7.640
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  10 in total

1.  Relationships of Long-Term Smoking and Moist Snuff Consumption With a DNA Methylation Age Relevant Smoking Index: An Analysis in Buccal Cells.

Authors:  Jamaji C Nwanaji-Enwerem; Andres Cardenas; Peter R Chai; Marc G Weisskopf; Andrea A Baccarelli; Edward W Boyer
Journal:  Nicotine Tob Res       Date:  2019-08-19       Impact factor: 4.244

2.  The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.

Authors:  Richard J Acton; Wei Yuan; Fei Gao; Yudong Xia; Emma Bourne; Eva Wozniak; Jordana Bell; Karen Lillycrop; Jun Wang; Elaine Dennison; Nicholas C Harvey; Charles A Mein; Tim D Spector; Pirro G Hysi; Cyrus Cooper; Christopher G Bell
Journal:  Nat Commun       Date:  2021-05-11       Impact factor: 14.919

Review 3.  Hallmarks of environmental insults.

Authors:  Annette Peters; Tim S Nawrot; Andrea A Baccarelli
Journal:  Cell       Date:  2021-03-02       Impact factor: 66.850

4.  Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study.

Authors:  Jacopo Dolcini; Haotian Wu; Jamaji C Nwanaji-Enwerem; Marianthi-Anna Kiomourtozlogu; Akin Cayir; Marco Sanchez-Guerra; Pantel Vokonas; Joel Schwarz; Andrea A Baccarelli
Journal:  Aging (Albany NY)       Date:  2020-02-02       Impact factor: 5.682

Review 5.  Molecular basis of ageing in chronic metabolic diseases.

Authors:  R Spinelli; L Parrillo; M Longo; P Florese; A Desiderio; F Zatterale; C Miele; G Alexander Raciti; F Beguinot
Journal:  J Endocrinol Invest       Date:  2020-05-01       Impact factor: 4.256

6.  Is your environment making you older? Molecular biomarkers and new approaches to investigate the influences of environmental chemicals through aging.

Authors:  Diddier Prada; Daniel Belsky; Andrea Baccarelli
Journal:  Med Lav       Date:  2021-02-23       Impact factor: 1.275

7.  Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus.

Authors:  Man Li; Litao Bao; Ping Zhu; Shuxia Wang
Journal:  Front Genet       Date:  2022-09-26       Impact factor: 4.772

8.  Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.

Authors:  Steve Horvath; Junko Oshima; George M Martin; Ake T Lu; Austin Quach; Howard Cohen; Sarah Felton; Mieko Matsuyama; Donna Lowe; Sylwia Kabacik; James G Wilson; Alex P Reiner; Anna Maierhofer; Julia Flunkert; Abraham Aviv; Lifang Hou; Andrea A Baccarelli; Yun Li; James D Stewart; Eric A Whitsel; Luigi Ferrucci; Shigemi Matsuyama; Kenneth Raj
Journal:  Aging (Albany NY)       Date:  2018-07-26       Impact factor: 5.682

9.  DNA methylation GrimAge strongly predicts lifespan and healthspan.

Authors:  Ake T Lu; Austin Quach; James G Wilson; Alex P Reiner; Abraham Aviv; Kenneth Raj; Lifang Hou; Andrea A Baccarelli; Yun Li; James D Stewart; Eric A Whitsel; Themistocles L Assimes; Luigi Ferrucci; Steve Horvath
Journal:  Aging (Albany NY)       Date:  2019-01-21       Impact factor: 5.682

10.  CancerClock: A DNA Methylation Age Predictor to Identify and Characterize Aging Clock in Pan-Cancer.

Authors:  Tongtong Zhu; Yue Gao; Junwei Wang; Xin Li; Shipeng Shang; Yanxia Wang; Shuang Guo; Hanxiao Zhou; Hongjia Liu; Dailin Sun; Hong Chen; Li Wang; Shangwei Ning
Journal:  Front Bioeng Biotechnol       Date:  2019-12-04
  10 in total

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