Hanna Kampling1, Oskar Mittag2, Stephan Herpertz3, Harald Baumeister4, Bernd Kulzer5, Frank Petrak6. 1. Section of Health Care Research and Rehabilitation Research, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 49, D-79115 Freiburg, Germany. Electronic address: hanna.kampling@uniklinik-freiburg.de. 2. Section of Health Care Research and Rehabilitation Research, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 49, D-79115 Freiburg, Germany. Electronic address: oskar.mittag@uniklinik-freiburg.de. 3. Department of Psychosomatic Medicine and Psychotherapy, LWL-University Clinic Bochum - Ruhr-University Bochum, Alexandrinenstrasse 1-3, D-44791 Bochum, Germany. Electronic address: stephan.herpertz@ruhr-uni-bochum.de. 4. University of Ulm, Institute of Psychology and Education, Department of Clinical Psychology and Psychotherapy, Albert-Einstein-Allee 47, D-89069 Ulm, Germany. Electronic address: harald.baumeister@uni-ulm.de. 5. Diabetes Center Mergentheim, Klotzbücher Str. 12, D-97980 Bad Mergentheim, Germany; Research Institute of the Diabetes Academy Mergentheim, Klotzbücher Str. 12, D-97980 Bad Mergentheim, Germany; Department of Clinical Psychology and Psychotherapy, Otto-Friedrich-University of Bamberg, Markusplatz 3, D-96047 Bamberg, Germany. Electronic address: kulzer@diabetes-zentrum.de. 6. Department of Psychosomatic Medicine and Psychotherapy, LWL-University Clinic Bochum - Ruhr-University Bochum, Alexandrinenstrasse 1-3, D-44791 Bochum, Germany; Center for Psychotherapy Wiesbaden, Sonnenberger Str. 20, D-65193 Wiesbaden, Germany. Electronic address: mail@dr-frank-petrak.de.
Abstract
AIMS: The longitudinal association between glycemic control with depression, anxiety or diabetes-related distress in type 1 diabetes is poorly understood. Therefore, we examined long-term trajectories of HbA1c in a new-onset cohort of adults with type 1 diabetes, and analyzed associations with depression, anxiety, and diabetes-related distress. METHODS: We included 313 newly diagnosed adults with type 1 diabetes in a prospective multicenter cohort study. Depression, anxiety, and diabetes-related distress were assessed starting with the diabetes diagnosis and at five annual surveys. HbA1c-measurements started with the one-year follow-up. HbA1c trajectories were analyzed applying Growth mixture modeling, while prediction of membership in the trajectories classes was analyzed using multiple regression, and one-way ANOVA/Chi2 to identify differences between classes. RESULTS: Average HbA1c increased constantly: follow-up at 1-year 6.5% (48 mmol/mol), 2-years 6.9% (52 mmol/mol), 3-years 7.1% (54 mmol/mol), 4-years 7.1% (54 mmol/mol), and 5-years 7.4% (57 mmol/mol). HbA1c trajectories included one 'good control' and three 'poor control' (52% of patients) classes. At the five-year follow-up, mean HbA1c was 6.3% (45 mmol/mol) in the 'good control' class, and ranging from 7.9% (63 mmol/mol) to 9.0% (75 mmol/mol) in the three 'poor control' classes. Classes were neither predicable, nor differentiated by depression, anxiety, or diabetes-related distress. CONCLUSIONS: We identified distinct trajectories of glycemic control. Depression and anxiety were highly prevalent but they neither predicted 'poor'/'good' glycemic control trajectories nor were they associated with glycemic control at any assessment point.
AIMS: The longitudinal association between glycemic control with depression, anxiety or diabetes-related distress in type 1 diabetes is poorly understood. Therefore, we examined long-term trajectories of HbA1c in a new-onset cohort of adults with type 1 diabetes, and analyzed associations with depression, anxiety, and diabetes-related distress. METHODS: We included 313 newly diagnosed adults with type 1 diabetes in a prospective multicenter cohort study. Depression, anxiety, and diabetes-related distress were assessed starting with the diabetes diagnosis and at five annual surveys. HbA1c-measurements started with the one-year follow-up. HbA1c trajectories were analyzed applying Growth mixture modeling, while prediction of membership in the trajectories classes was analyzed using multiple regression, and one-way ANOVA/Chi2 to identify differences between classes. RESULTS: Average HbA1c increased constantly: follow-up at 1-year 6.5% (48 mmol/mol), 2-years 6.9% (52 mmol/mol), 3-years 7.1% (54 mmol/mol), 4-years 7.1% (54 mmol/mol), and 5-years 7.4% (57 mmol/mol). HbA1c trajectories included one 'good control' and three 'poor control' (52% of patients) classes. At the five-year follow-up, mean HbA1c was 6.3% (45 mmol/mol) in the 'good control' class, and ranging from 7.9% (63 mmol/mol) to 9.0% (75 mmol/mol) in the three 'poor control' classes. Classes were neither predicable, nor differentiated by depression, anxiety, or diabetes-related distress. CONCLUSIONS: We identified distinct trajectories of glycemic control. Depression and anxiety were highly prevalent but they neither predicted 'poor'/'good' glycemic control trajectories nor were they associated with glycemic control at any assessment point.
Authors: Magdalena Beran; Rutendo Muzambi; Anouk Geraets; Juan Rafael Albertorio-Diaz; Marcel C Adriaanse; Marjolein M Iversen; Andrzej Kokoszka; Giesje Nefs; Arie Nouwen; Frans Pouwer; Jörg W Huber; Andreas Schmitt; Miranda T Schram Journal: Diabet Med Date: 2021-09-05 Impact factor: 4.213