Literature DB >> 2969831

Rat cardiac hypertrophy. Altered sodium-calcium exchange activity in sarcolemmal vesicles.

R Hanf1, I Drubaix, F Marotte, L G Lelievre.   

Abstract

The sodium-calcium exchange activity has been studied in sarcolemmal vesicles isolated from rat ventricles hypertrophied by pressure overload. 4 weeks after aortic stenosis the degree of hypertrophy varied from 30 to 70%. The Na+-dependent 45Ca2+ influx and efflux were up to 50% decreased and the sensitivity to Ca2+ was 13-fold lower in vesicles from hypertrophied heart as compared to those from normal heart. However, the Na+,K+-ATPase activity, the orientation of the vesicles and the passive Ca2+ permeability were found to be similar in the two heart groups. These results indicate that the sarcolemmal Na+/Ca2+ exchange activity could be qualitatively and/or quantitatively changed in hypertrophied rat heart.

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Year:  1988        PMID： 2969831     DOI： 10.1016/0014-5793(88)80303-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

Review 1.  Calcium transport proteins in the nonfailing and failing heart: gene expression and function.

Authors:  M Wankerl; K Schwartz
Journal:  J Mol Med (Berl)       Date:  1995-10       Impact factor: 4.599

2.  Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation.

Authors:  H Schunkert; V J Dzau; S S Tang; A T Hirsch; C S Apstein; B H Lorell
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

3.  Effect of haemodynamic pressure overload of the adult ferret right ventricle on inotropic responsiveness to external calcium and rest periods.

Authors:  S Baudet; J Noireaud; C Léoty
Journal:  Pflugers Arch       Date:  1992-04       Impact factor: 3.657

Review 4.  The long QT interval is not only inherited but is also linked to cardiac hypertrophy.

Authors:  Bernard Swynghedauw; Christophe Baillard; Paul Milliez
Journal:  J Mol Med (Berl)       Date:  2003-05-15       Impact factor: 4.599

5.  Altered pattern of post-rest contractions in hypertrophied rabbit ventricle.

Authors:  I R Wendt; C L Gibbs; G Kotsanas; I R Young
Journal:  Heart Vessels       Date:  1991       Impact factor: 2.037

6.  Intracellular Na activity measurements in the control and hypertrophied heart of the ferret: an ion-sensitive micro-electrode study.

Authors:  S Baudet; J Noireaud; C Léoty
Journal:  Pflugers Arch       Date:  1991-05       Impact factor: 3.657

7.  Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding.

Authors:  Sara Gattoni; Åsmund Treu Røe; Jan Magnus Aronsen; Ivar Sjaastad; William E Louch; Nicolas P Smith; Steven A Niederer
Journal:  J Physiol       Date:  2017-05-21       Impact factor: 5.182
  7 in total

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