Gamal M Hasan1,2, Ayman A Al-Eyadhy1, Mohamed-Hani A Temsah1, Ali A Al-Haboob1, Mohammad A Alkhateeb1, Fahad Al-Sohime1. 1. Intensive Care Unit, Department of Pediatrics, King Khalid University Hospital and College of Medicine, King Saud University, Riyadh, Saudi Arabia. 2. Intensive Care Unit, Department of Pediatrics, Faculty of Medicine, Assiut University Children Hospital, Assiut University, Assiut, Egypt.
Abstract
OBJECTIVES: Evaluation of feasibility and effectiveness of Surviving Sepsis Campaign (SSC) Guidelines implementation at a Pediatric Intensive Care Unit (PICU) in Saudi Arabia to reduce severe sepsis associated mortality. DESIGN: Retrospective data analysis for a prospective quality improvement (QI) initiative. SETTINGS: PICU at King Saud University Medical City, Saudi Arabia. PARTICIPANTS: Children ≤14 years of age admitted to the PICU from July 2010 to March 2011 with suspected or proven sepsis. Comparisons were made to a previously admitted group of patients with sepsis from October 2009 to June 2010. INTERVENTIONS: Adaptation and implementation of the Surviving Sepsis Campaign-Clinical Practice Guidelines (SSC-CPGs) through AGREE instrument and ADAPTE process. MAIN OUTCOME MEASURES: We reported pre- and post-implementation outcome of interest for this QI initiative, annual sepsis-related mortality rate. Furthermore, we reported follow-up of annual mortality rate until December 2016. RESULTS: Sixty-five patients was included in the study (42 in post-guidelines implementation group and 23 in pre-guidelines implementation group). Mortality was insignificantly lower in the post-implementation group (26.2% vs. 47.8%; P = 0.079). However, when adjusted for severity, identified by number of failing organs in the multivariate regression analysis, the mortality difference was favorable for the post-implementation group (P = 0.006). The lower sepsis-related mortality rate was also sustained, with an average mortality rate of 15.11% for the subsequent years (2012-16). CONCLUSIONS: Adaptation and implementation of SSC Guidelines in our setting support its feasibility and potential benefits. However, a larger study is recommended to explore detailed compliance rates.
OBJECTIVES: Evaluation of feasibility and effectiveness of Surviving Sepsis Campaign (SSC) Guidelines implementation at a Pediatric Intensive Care Unit (PICU) in Saudi Arabia to reduce severe sepsis associated mortality. DESIGN: Retrospective data analysis for a prospective quality improvement (QI) initiative. SETTINGS: PICU at King Saud University Medical City, Saudi Arabia. PARTICIPANTS: Children ≤14 years of age admitted to the PICU from July 2010 to March 2011 with suspected or proven sepsis. Comparisons were made to a previously admitted group of patients with sepsis from October 2009 to June 2010. INTERVENTIONS: Adaptation and implementation of the Surviving Sepsis Campaign-Clinical Practice Guidelines (SSC-CPGs) through AGREE instrument and ADAPTE process. MAIN OUTCOME MEASURES: We reported pre- and post-implementation outcome of interest for this QI initiative, annual sepsis-related mortality rate. Furthermore, we reported follow-up of annual mortality rate until December 2016. RESULTS: Sixty-five patients was included in the study (42 in post-guidelines implementation group and 23 in pre-guidelines implementation group). Mortality was insignificantly lower in the post-implementation group (26.2% vs. 47.8%; P = 0.079). However, when adjusted for severity, identified by number of failing organs in the multivariate regression analysis, the mortality difference was favorable for the post-implementation group (P = 0.006). The lower sepsis-related mortality rate was also sustained, with an average mortality rate of 15.11% for the subsequent years (2012-16). CONCLUSIONS: Adaptation and implementation of SSC Guidelines in our setting support its feasibility and potential benefits. However, a larger study is recommended to explore detailed compliance rates.
Authors: Mohamed O Humoodi; Mona A Aldabbagh; Maher M Salem; Yousef M Al Talhi; Sara M Osman; Mohammed Bakhsh; Abdullah M Alzahrani; Maha Azzam Journal: BMC Pediatr Date: 2021-05-07 Impact factor: 2.125
Authors: Ayman Al-Eyadhy; Mohamad-Hani Temsah; Gamal M Hasan; Mohammed Almazyad; Ali A Alhaboob; Majed Alabdulhafid; Fahad Alsohime; Ahmed S Alzahrani; Abdullah M Alammari; Faisal S Abunohaiah; Nawaf F Alfawzan; Suhail S Alghamdi Journal: Saudi Med J Date: 2021-11 Impact factor: 1.422