Fousseyni Traoré1, Fatou Sylla2, Boubacar Togo1, Bakarou Kamaté3, Konimba Diabaté4, Abdoul Aziz Diakité1, Hawa Diall1, Fatoumata Dicko1, Mariam Sylla1, Pierre Bey5, Laurence Desjardins5, Anne Gagnepain-Lacheteau6, Carole Coze7, Mhamed Harif8, François Doz9. 1. Pediatric Department, Pediatric Oncology Unit, CHU Gabriel Touré, Bamako, Mali. 2. Pediatric Ophtalmology Department, Institute of African Tropical Ophthalmology, Bamako, Mali. 3. Histopathology Department, CHU Point G, Bamako, Mali. 4. Radiation Therapy Department, Hôpital du Mali, Bamako, Mali. 5. Pediatric Oncology Department, Institut Curie, Paris, France. 6. Sanofi Espoir Foundation, Sanofi Espoir Foundation, Paris, France. 7. Pediatric Unit, Assistance Publique Hopitaux de Marseille, Aix-Marseille University, Marseille, France. 8. Pediatric Oncology Department, CHU Mohammed VI, Marrakech, Morrocco. 9. Pediatric Oncology Department, Centre SIREDO (Soins, Innovation, Recherche en oncologie de l'enfant, l'adolescent et l'adulte jeune), Institut Curie et Université Paris-Descartes, Paris, France.
Abstract
BACKGROUND: Retinoblastoma (Rb) is the most common intraocular primary malignancy in children. In industrialised countries, the cure rate is about 95%. We present the results of a prospective study on the management of Rb in the paediatric oncology unit of Gabriel Touré Teaching Hospital and African Institute of Tropical Ophthalmology, from November 1, 2011 to December 31, 2015. PROCEDURE: The aims of this prospective study were to evaluate the treatment of localised Rb, ocular prosthesis after enucleation, conservative management for bilateral Rb as well as survival rates in all patients. Patients with early stage Rb at diagnosis were included. The treatment was performed according to the retinoblastoma treatment guidelines of the French-African Paediatric Oncology Group. RESULTS: Eighty-eight patients were included in the study. Sex ratio was 1:1 (M = 44, F = 44). Median age at diagnosis was 3 years (range: 2 months-5 years). Unilateral intraocular Rb was predominant (n = 50; 56.8%). Conservative treatments were performed on nine eyes in nine patients. Overall survival and event-free survival of the entire cohort at the end of 4 years were 73% (95% CI 60.8-81.2%) and 59% (95% CI 47.9-69.5%), respectively, with a median follow-up of 3.7 years (0.1-5.6 years). In conclusion, early enucleation in early stage of Rb can improve outcomes in resource-limited countries. Delayed enucleation and refusal of adherence to treatment are still major concerns and remain a barrier to improving overall patient survival.
BACKGROUND:Retinoblastoma (Rb) is the most common intraocular primary malignancy in children. In industrialised countries, the cure rate is about 95%. We present the results of a prospective study on the management of Rb in the paediatric oncology unit of Gabriel Touré Teaching Hospital and African Institute of Tropical Ophthalmology, from November 1, 2011 to December 31, 2015. PROCEDURE: The aims of this prospective study were to evaluate the treatment of localised Rb, ocular prosthesis after enucleation, conservative management for bilateral Rb as well as survival rates in all patients. Patients with early stage Rb at diagnosis were included. The treatment was performed according to the retinoblastoma treatment guidelines of the French-African Paediatric Oncology Group. RESULTS: Eighty-eight patients were included in the study. Sex ratio was 1:1 (M = 44, F = 44). Median age at diagnosis was 3 years (range: 2 months-5 years). Unilateral intraocular Rb was predominant (n = 50; 56.8%). Conservative treatments were performed on nine eyes in nine patients. Overall survival and event-free survival of the entire cohort at the end of 4 years were 73% (95% CI 60.8-81.2%) and 59% (95% CI 47.9-69.5%), respectively, with a median follow-up of 3.7 years (0.1-5.6 years). In conclusion, early enucleation in early stage of Rb can improve outcomes in resource-limited countries. Delayed enucleation and refusal of adherence to treatment are still major concerns and remain a barrier to improving overall patient survival.
Authors: Lara Elis Alberici Delsin; Karina Bezerra Salomao; Julia Alejandra Pezuk; Maria Sol Brassesco Journal: J Cancer Res Clin Oncol Date: 2018-10-22 Impact factor: 4.553
Authors: Ido Didi Fabian; Elhassan Abdallah; Shehu U Abdullahi; Rula A Abdulqader; Sahadatou Adamou Boubacar; Dupe S Ademola-Popoola; Adedayo Adio; Armin R Afshar; Priyanka Aggarwal; Ada E Aghaji; Alia Ahmad; Marliyanti N R Akib; Lamis Al Harby; Mouroge H Al Ani; Aygun Alakbarova; Silvia Alarcón Portabella; Safaa A F Al-Badri; Ana Patricia A Alcasabas; Saad A Al-Dahmash; Amanda Alejos; Ernesto Alemany-Rubio; Amadou I Alfa Bio; Yvania Alfonso Carreras; Christiane Al-Haddad; Hamoud H Y Al-Hussaini; Amany M Ali; Donjeta B Alia; Mazin F Al-Jadiry; Usama Al-Jumaily; Hind M Alkatan; Charlotta All-Eriksson; Ali A R M Al-Mafrachi; Argentino A Almeida; Khalifa M Alsawidi; Athar A S M Al-Shaheen; Entissar H Al-Shammary; Primawita O Amiruddin; Romanzo Antonino; Nicholas J Astbury; Hatice T Atalay; La-Ongsri Atchaneeyasakul; Rose Atsiaya; Taweevat Attaseth; Than H Aung; Silvia Ayala; Baglan Baizakova; Julia Balaguer; Ruhengiz Balayeva; Walentyna Balwierz; Honorio Barranco; Covadonga Bascaran; Maja Beck Popovic; Raquel Benavides; Sarra Benmiloud; Nissrine Bennani Guebessi; Rokia C Berete; Jesse L Berry; Anirban Bhaduri; Sunil Bhat; Shelley J Biddulph; Eva M Biewald; Nadia Bobrova; Marianna Boehme; H C Boldt; Maria Teresa B C Bonanomi; Norbert Bornfeld; Gabrielle C Bouda; Hédi Bouguila; Amaria Boumedane; Rachel C Brennan; Bénédicte G Brichard; Jassada Buaboonnam; Patricia Calderón-Sotelo; Doris A Calle Jara; Jayne E Camuglia; Miriam R Cano; Michael Capra; Nathalie Cassoux; Guilherme Castela; Luis Castillo; Jaume Català-Mora; Guillermo L Chantada; Shabana Chaudhry; Sonal S Chaugule; Argudit Chauhan; Bhavna Chawla; Violeta S Chernodrinska; Faraja S Chiwanga; Tsengelmaa Chuluunbat; Krzysztof Cieslik; Ruellyn L Cockcroft; Codruta Comsa; Zelia M Correa; Maria G Correa Llano; Timothy W Corson; Kristin E Cowan-Lyn; Monika Csóka; Xuehao Cui; Isac V Da Gama; Wantanee Dangboon; Anirban Das; Sima Das; Jacquelyn M Davanzo; Alan Davidson; Patrick De Potter; Karina Q Delgado; Hakan Demirci; Laurence Desjardins; Rosdali Y Diaz Coronado; Helen Dimaras; Andrew J Dodgshun; Craig Donaldson; Carla R Donato Macedo; Monica D Dragomir; Yi Du; Magritha Du Bruyn; Kemala S Edison; I Wayan Eka Sutyawan; Asmaa El Kettani; Amal M Elbahi; James E Elder; Dina Elgalaly; Alaa M Elhaddad; Moawia M Ali Elhassan; Mahmoud M Elzembely; Vera A Essuman; Ted Grimbert A Evina; Zehra Fadoo; Adriana C Fandiño; Mohammad Faranoush; Oluyemi Fasina; Delia D P G Fernández; Ana Fernández-Teijeiro; Allen Foster; Shahar Frenkel; Ligia D Fu; Soad L Fuentes-Alabi; Brenda L Gallie; Moira Gandiwa; Juan L Garcia; David García Aldana; Pascale Y Gassant; Jennifer A Geel; Fariba Ghassemi; Ana V Girón; Zelalem Gizachew; Marco A Goenz; Aaron S Gold; Maya Goldberg-Lavid; Glen A Gole; Nir Gomel; Efren Gonzalez; Graciela Gonzalez Perez; Liudmira González-Rodríguez; Henry N Garcia Pacheco; Jaime Graells; Liz Green; Pernille A Gregersen; Nathalia D A K Grigorovski; Koffi M Guedenon; D Sanjeeva Gunasekera; Ahmet K Gündüz; Himika Gupta; Sanjiv Gupta; Theodora Hadjistilianou; Patrick Hamel; Syed A Hamid; Norhafizah Hamzah; Eric D Hansen; J William Harbour; M Elizabeth Hartnett; Murat Hasanreisoglu; Sadiq Hassan; Shadab Hassan; Stanislava Hederova; Jose Hernandez; Lorelay Marie Carcamo Hernandez; Laila Hessissen; Diriba F Hordofa; Laura C Huang; G B Hubbard; Marlies Hummlen; Kristina Husakova; Allawi N Hussein Al-Janabi; Russo Ida; Vesna R Ilic; Vivekaraj Jairaj; Irfan Jeeva; Helen Jenkinson; Xunda Ji; Dong Hyun Jo; Kenneth P Johnson; William J Johnson; Michael M Jones; Theophile B Amani Kabesha; Rolande L Kabore; Swathi Kaliki; Abubakar Kalinaki; Mehmet Kantar; Ling-Yuh Kao; Tamar Kardava; Rejin Kebudi; Tomas Kepak; Naama Keren-Froim; Zohora J Khan; Hussain A Khaqan; Phara Khauv; Wajiha J Kheir; Vikas Khetan; Alireza Khodabande; Zaza Khotenashvili; Jonathan W Kim; Jeong Hun Kim; Hayyam Kiratli; Tero T Kivelä; Artur Klett; Jess Elio Kosh Komba Palet; Dalia Krivaitiene; Mariana Kruger; Kittisak Kulvichit; Mayasari W Kuntorini; Alice Kyara; Eva S Lachmann; Carol P S Lam; Geoffrey C Lam; Scott A Larson; Slobodanka Latinovic; Kelly D Laurenti; Bao Han A Le; Karin Lecuona; Amy A Leverant; Cairui Li; Ben Limbu; Quah Boon Long; Juan P López; Robert M Lukamba; Livia Lumbroso; Sandra Luna-Fineman; Delfitri Lutfi; Lesia Lysytsia; George N Magrath; Amita Mahajan; Abdul Rahim Majeed; Erika Maka; Mayuri Makan; Emil K Makimbetov; Chatonda Manda; Nieves Martín Begue; Lauren Mason; John O Mason; Ibrahim O Matende; Miguel Materin; Clarissa C D S Mattosinho; Marchelo Matua; Ismail Mayet; Freddy B Mbumba; John D McKenzie; Aurora Medina-Sanson; Azim Mehrvar; Aemero A Mengesha; Vikas Menon; Gary John V D Mercado; Marilyn B Mets; Edoardo Midena; Divyansh K C Mishra; Furahini G Mndeme; Ahmed A Mohamedani; Mona T Mohammad; Annette C Moll; Margarita M Montero; Rosa A Morales; Claude Moreira; Prithvi Mruthyunjaya; Mchikirwa S Msina; Gerald Msukwa; Sangeeta S Mudaliar; Kangwa I Muma; Francis L Munier; Gabriela Murgoi; Timothy G Murray; Kareem O Musa; Asma Mushtaq; Hamzah Mustak; Okwen M Muyen; Gita Naidu; Akshay Gopinathan Nair; Larisa Naumenko; Paule Aïda Ndoye Roth; Yetty M Nency; Vladimir Neroev; Hang Ngo; Rosa M Nieves; Marina Nikitovic; Elizabeth D Nkanga; Henry Nkumbe; Murtuza Nuruddin; Mutale Nyaywa; Ghislaine Obono-Obiang; Ngozi C Oguego; Andrzej Olechowski; Scott C N Oliver; Peter Osei-Bonsu; Diego Ossandon; Manuel A Paez-Escamilla; Halimah Pagarra; Sally L Painter; Vivian Paintsil; Luisa Paiva; Bikramjit P Pal; Mahesh Shanmugam Palanivelu; Ruzanna Papyan; Raffaele Parrozzani; Manoj Parulekar; Claudia R Pascual Morales; Katherine E Paton; Katarzyna Pawinska-Wasikowska; Jacob Pe'er; Armando Peña; Sanja Peric; Chau T M Pham; Remezo Philbert; David A Plager; Pavel Pochop; Rodrigo A Polania; Vladimir G Polyakov; Manca T Pompe; Jonathan J Pons; Daphna Prat; Vireak Prom; Ignatius Purwanto; Ali O Qadir; Seema Qayyum; Jiang Qian; Ardizal Rahman; Salman Rahman; Jamalia Rahmat; Purnima Rajkarnikar; Rajesh Ramanjulu; Aparna Ramasubramanian; Marco A Ramirez-Ortiz; Léa Raobela; Riffat Rashid; M Ashwin Reddy; Ehud Reich; Lorna A Renner; David Reynders; Dahiru Ribadu; Mussagy M Riheia; Petra Ritter-Sovinz; Duangnate Rojanaporn; Livia Romero; Soma R Roy; Raya H Saab; Svetlana Saakyan; Ahmed H Sabhan; Mandeep S Sagoo; Azza M A Said; Rohit Saiju; Beatriz Salas; Sonsoles San Román Pacheco; Gissela L Sánchez; Phayvanh Sayalith; Trish A Scanlan; Amy C Schefler; Judy Schoeman; Ahad Sedaghat; Stefan Seregard; Rachna Seth; Ankoor S Shah; Shawkat A Shakoor; Manoj K Sharma; Sadik T Sherief; Nandan G Shetye; Carol L Shields; Sorath Noorani Siddiqui; Sidi Sidi Cheikh; Sónia Silva; Arun D Singh; Niharika Singh; Usha Singh; Penny Singha; Rita S Sitorus; Alison H Skalet; Hendrian D Soebagjo; Tetyana Sorochynska; Grace Ssali; Andrew W Stacey; Sandra E Staffieri; Erin D Stahl; Christina Stathopoulos; Branka Stirn Kranjc; David K Stones; Caron Strahlendorf; Maria Estela Coleoni Suarez; Sadia Sultana; Xiantao Sun; Meryl Sundy; Rosanne Superstein; Eddy Supriyadi; Supawan Surukrattanaskul; Shigenobu Suzuki; Karel Svojgr; Fatoumata Sylla; Gevorg Tamamyan; Deborah Tan; Alketa Tandili; Fanny F Tarrillo Leiva; Maryam Tashvighi; Bekim Tateshi; Edi S Tehuteru; Luiz F Teixeira; Kok Hoi Teh; Tuyisabe Theophile; Helen Toledano; Doan L Trang; Fousseyni Traoré; Sumalin Trichaiyaporn; Samuray Tuncer; Harba Tyau-Tyau; Ali B Umar; Emel Unal; Ogul E Uner; Steen F Urbak; Tatiana L Ushakova; Rustam H Usmanov; Sandra Valeina; Milo van Hoefen Wijsard; Adisai Varadisai; Liliana Vasquez; Leon O Vaughan; Nevyana V Veleva-Krasteva; Nishant Verma; Andi A Victor; Maris Viksnins; Edwin G Villacís Chafla; Vicktoria Vishnevskia-Dai; Tushar Vora; Antonio E Wachtel; Werner Wackernagel; Keith Waddell; Patricia D Wade; Amina H Wali; Yi-Zhuo Wang; Avery Weiss; Matthew W Wilson; Amelia D C Wime; Atchareeya Wiwatwongwana; Damrong Wiwatwongwana; Charlotte Wolley Dod; Phanthipha Wongwai; Daoman Xiang; Yishuang Xiao; Jason C Yam; Huasheng Yang; Jenny M Yanga; Muhammad A Yaqub; Vera A Yarovaya; Andrey A Yarovoy; Huijing Ye; Yacoub A Yousef; Putu Yuliawati; Arturo M Zapata López; Ekhtelbenina Zein; Chengyue Zhang; Yi Zhang; Junyang Zhao; Xiaoyu Zheng; Katsiaryna Zhilyaeva; Nida Zia; Othman A O Ziko; Marcia Zondervan; Richard Bowman Journal: JAMA Oncol Date: 2020-05-01 Impact factor: 31.777