| Literature DB >> 29693652 |
Soon Hee Kim1, Yeung Kyu Yeon1, Jung Min Lee1, Janet Ren Chao2, Young Jin Lee1, Ye Been Seo1, Md Tipu Sultan1, Ok Joo Lee1, Ji Seung Lee1, Sung-Il Yoon3, In-Sun Hong4, Gilson Khang5, Sang Jin Lee6, James J Yoo6, Chan Hum Park7,8.
Abstract
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements.Entities:
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Year: 2018 PMID： 29693652 PMCID： PMC5915392 DOI： 10.1038/s41467-018-03759-y
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919