Literature DB >> 29692423

Publisher Correction: PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus.

Matthew T Dinday1, Kelly M Girskis1, Sunyoung Lee2, Scott C Baraban1, Robert F Hunt3.   

Abstract

A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper.

Entities:  

Year:  2018        PMID: 29692423      PMCID: PMC5915572          DOI: 10.1038/s41598-018-24610-w

Source DB:  PubMed          Journal:  Sci Rep        ISSN: 2045-2322            Impact factor:   4.379


Correction to: Scientific Reports 10.1038/s41598-017-08809-x, published online 15 August 2017 This Article contains an error in the order of the Figures. Figures 2 and 3 were published as Figures 3, and 2 respectively. The correct Figures 2 and 3 appear below as Figures 1 and 2 respectively. The Figure legends are correct.
Figure 1

Fewer PV+ and SST+, but not CR+, GABAergic interneurons in Pafah1b1+/− dentate gyrus. (a) Immunostaining for GAD67-GFP (green), PV (magenta) and DAPI (blue) in wild-type and Pafah1b1+/− mice at P30. (b) Immunostaining for GAD67-GFP (green), SST (magenta) and DAPI (blue) in wild-type and Pafah1b1+/− mice at P30. (c) Immunostaining for GAD67-GFP (green), CR (magenta) and DAPI (blue) in wild-type and Pafah1b1+/− mice at P30. (d–f) Quantification of PV- (d), SST- (e) and CR-expressing (f) GABA neurons in dentate gyrus of wild-type and Pafah1b1+/− mice at P30 (n = 4 for each genotype). Error bars represent s.e.m., *p < 0.05, **p < 0.01.

Figure 2

Dramatic change in synaptic inhibition and excitation in dentate granule cells of Pafah1b1+/− mice. (a) Example voltage-clamp recordings of sIPSCs and sEPSCs recorded from granule cells in slices of a wild-type control and Pafah1b1 mutant. (b–d) Average sEPSC frequency (b), sIPSC frequency (c) and sEPSC:sIPSC ratio (d) in granule cells of wild-type and Pafah1b1+/− mice. (e–g) Average mEPSC frequency (e), mIPSC frequency (f) and mEPSC:sIPSC ratio (g) in granule cells of wild-type and Pafah1b1+/− mice. Error bars represent s.e.m., *p < 0.05, **p < 0.01.

Fewer PV+ and SST+, but not CR+, GABAergic interneurons in Pafah1b1+/− dentate gyrus. (a) Immunostaining for GAD67-GFP (green), PV (magenta) and DAPI (blue) in wild-type and Pafah1b1+/− mice at P30. (b) Immunostaining for GAD67-GFP (green), SST (magenta) and DAPI (blue) in wild-type and Pafah1b1+/− mice at P30. (c) Immunostaining for GAD67-GFP (green), CR (magenta) and DAPI (blue) in wild-type and Pafah1b1+/− mice at P30. (d–f) Quantification of PV- (d), SST- (e) and CR-expressing (f) GABA neurons in dentate gyrus of wild-type and Pafah1b1+/− mice at P30 (n = 4 for each genotype). Error bars represent s.e.m., *p < 0.05, **p < 0.01. Dramatic change in synaptic inhibition and excitation in dentate granule cells of Pafah1b1+/− mice. (a) Example voltage-clamp recordings of sIPSCs and sEPSCs recorded from granule cells in slices of a wild-type control and Pafah1b1 mutant. (b–d) Average sEPSC frequency (b), sIPSC frequency (c) and sEPSC:sIPSC ratio (d) in granule cells of wild-type and Pafah1b1+/− mice. (e–g) Average mEPSC frequency (e), mIPSC frequency (f) and mEPSC:sIPSC ratio (g) in granule cells of wild-type and Pafah1b1+/− mice. Error bars represent s.e.m., *p < 0.05, **p < 0.01.
  1 in total

1.  Properties of the epileptiform activity in the cingulate cortex of a mouse model of LIS1 dysfunction.

Authors:  E Domínguez-Sala; A Andreu-Cervera; P Martín-Climent; R Murcia-Ramón; S Martínez; Emilio Geijo-Barrientos
Journal:  Brain Struct Funct       Date:  2022-02-01       Impact factor: 3.748

  1 in total

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