Literature DB >> 29692219

Uncovering novel landscape of cardiovascular diseases and therapeutic targets for cardioprotection via long noncoding RNA-miRNA-mRNA axes.

Liang He1,2, Yan Chen1, Shuqing Hao1, Jinqiao Qian1.   

Abstract

Protein coding sequences account for around 3% of the human genome, the rest are noncoding RNA (ncRNA) including long ncRNA (lncRNA) and miRNA. Accumulating evidence indicates that lncRNAs and miRNAs are candidate biomarkers for diagnosis, prognosis and therapy of cardiovascular diseases. The lncRNAs act as sponge-like effects on numerous miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of lncRNA-miRNA-mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted. Herein, this review discusses emerging roles of lncRNA-miRNA-mRNA axis in cardiovascular pathophysiology and regulation, with a novel focus on cardioprotective network activities of the two subgroup ncRNAs.

Entities:  

Keywords:  apoptosis; atherosclerosis; autophagy; ceRNA; endothelial cells; necrosis

Mesh：

Substances：

Year:  2018        PMID： 29692219     DOI： 10.2217/epi-2017-0176

Source DB:  PubMed          Journal:  Epigenomics        ISSN： 1750-192X            Impact factor:   4.778


  18 in total

1.  Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

Authors:  Suowen Xu; Danielle Kamato; Peter J Little; Shinichi Nakagawa; Jaroslav Pelisek; Zheng Gen Jin
Journal:  Pharmacol Ther       Date:  2018-11-13       Impact factor: 12.310

2.  LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation.

Authors:  Gaolian Zhang; Jianhui Guo; Jing Zeng; Xiaoning Zhang; Rui Chen; Gang Wang; Weibin Liang
Journal:  Metab Brain Dis       Date:  2022-06-09       Impact factor: 3.655

3.  PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis.

Authors:  Caiqiang Huang; Runguang Li; Changsheng Yang; Rui Ding; Qingchu Li; Denghui Xie; Rongkai Zhang; Yiyan Qiu
Journal:  Exp Mol Med       Date:  2021-05-19       Impact factor: 8.718

4.  Genome-wide data mining to construct a competing endogenous RNA network and reveal the pivotal therapeutic targets of Parkinson's disease.

Authors:  Jing Zhang; Ruiying Chen; Fan Shi; Pan Yang; Kun Sun; Xiaojing Yang; Yulan Jin
Journal:  J Cell Mol Med       Date:  2020-12-15       Impact factor: 5.310

5.  LncRNA expression profile and ceRNA analysis in tomato during flowering.

Authors:  Zhenchao Yang; Chengcheng Yang; Zhengyan Wang; Zhao Yang; Danyan Chen; Yongjun Wu
Journal:  PLoS One       Date:  2019-01-17       Impact factor: 3.240

6.  A novel lncRNA-miRNA-mRNA triple network identifies lncRNA TWF1 as an important regulator of miRNA and gene expression in coronary artery disease.

Authors:  Liu Miao; Rui-Xing Yin; Qing-Hui Zhang; Xi-Jiang Hu; Feng Huang; Wu-Xian Chen; Xiao-Li Cao; Jin-Zhen Wu
Journal:  Nutr Metab (Lond)       Date:  2019-06-06       Impact factor: 4.169

Review 7.  Unveiling ncRNA regulatory axes in atherosclerosis progression.

Authors:  Estanislao Navarro; Adrian Mallén; Josep M Cruzado; Joan Torras; Miguel Hueso
Journal:  Clin Transl Med       Date:  2020-02-03

Review 8.  Functions and Regulatory Mechanisms of lncRNAs in Skeletal Myogenesis, Muscle Disease and Meat Production.

Authors:  Shanshan Wang; Jianjun Jin; Zaiyan Xu; Bo Zuo
Journal:  Cells       Date:  2019-09-19       Impact factor: 6.600

9.  Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis.

Authors:  Shushan Yan; Pingping Wang; Jinghua Wang; Jinghan Yang; Hongying Lu; Chengwen Jin; Min Cheng; Donghua Xu
Journal:  Front Immunol       Date:  2019-09-18       Impact factor: 7.561

10.  Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway.

Authors:  Shan Lei; Zhiwei He; Tengxiang Chen; Xingjun Guo; Zhirui Zeng; Yiyi Shen; Jianxin Jiang
Journal:  J Exp Clin Cancer Res       Date:  2019-11-20
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