Wilfred C de Vega1,2, Lauren Erdman3,4, Suzanne D Vernon5, Anna Goldenberg3,4, Patrick O McGowan1,2,6,7. 1. Department of Biological Sciences, University of Toronto, Scarborough, Toronto, Ontario, Canada. 2. Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada. 3. Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. 4. Genetics & Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada. 5. The Bateman Horne Center of Excellence, Salt Lake City, UT 84102, USA. 6. Department of Psychology, University of Toronto, Toronto, Ontario, Canada. 7. Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Abstract
AIM: To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores. METHODS: DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes. RESULTS: We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes. CONCLUSION: ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
AIM: To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores. METHODS: DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes. RESULTS: We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes. CONCLUSION: ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
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