Marion Taine1,2,3, Marie-Aline Charles1,2, Jacques Beltrand2,3,4, Jean Christophe Rozé5,6, Juliane Léger7,8, Jérémie Botton1,9, Barbara Heude1,2. 1. Early Determinants of Children's Health and Development Team (ORCHAD), Inserm UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Villejuif, France. 2. Paris Descartes University, Paris, France. 3. Department of Paediatric endocrinology, Necker Enfants Malades Hospital, Paris, France. 4. Inserm UMR 1016, Cochin Institute, Paris, France. 5. Department of Paediatric Medicine, Nantes University Hospital, Nantes, France. 6. Inserm CIC 1413, Clinical Investigation Center, Nantes University Hospital, Nantes, France. 7. Department of Paediatric Endocrinology, Robert Debré Hospital, Paris Diderot University, Paris, France. 8. DHU Protect, Inserm UMR 1141, Paris, France. 9. University Paris-Sud, University Paris-Saclay, F-92296, Châtenay-Malabry, France.
Abstract
BACKGROUND: Clinicians' interest in the long-term effects of early postnatal growth (EPG) is growing. There is compelling evidence linking rapid EPG with later cardiovascular risk, but its neurodevelopmental benefits still remain hypothetical in individuals born moderately preterm (MP) or small for gestational at term (SGAT). METHODS: The objective was to perform a systematic review of the relationship between EPG before age 3 years and neurodevelopmental outcome for individuals born MP (32-36 weeks' gestational age) or SGAT. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, 3 independent investigators searched for articles published on this topic in the Web of Science, EMBASE and PubMed from database inception to July 1, 2017. A detailed quality scale was used to evaluate articles. RESULTS: We selected 19 articles relying on 12 distinct study populations; 7 articles from 3 study populations were considered at moderate or high quality. The lack of standardisation of growth analysis methods prevented performing a meta-analysis. Overall, EPG was positively associated with neurodevelopmental outcome, especially Intelligence Quotient (IQ) when available. In this relationship, the first 6 months of life might be a critical period. Analysis of the few articles investigating the shape of the relationships revealed a non-linear association, with a plateau for IQ with higher weight gain, which suggests a possible ceiling effect. CONCLUSIONS: A positive association was generally found between EPG and neurodevelopmental outcome for individuals born MP or SGAT. Strategies for future epidemiological studies are suggested to improve the characterisation of this relationship.
BACKGROUND: Clinicians' interest in the long-term effects of early postnatal growth (EPG) is growing. There is compelling evidence linking rapid EPG with later cardiovascular risk, but its neurodevelopmental benefits still remain hypothetical in individuals born moderately preterm (MP) or small for gestational at term (SGAT). METHODS: The objective was to perform a systematic review of the relationship between EPG before age 3 years and neurodevelopmental outcome for individuals born MP (32-36 weeks' gestational age) or SGAT. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, 3 independent investigators searched for articles published on this topic in the Web of Science, EMBASE and PubMed from database inception to July 1, 2017. A detailed quality scale was used to evaluate articles. RESULTS: We selected 19 articles relying on 12 distinct study populations; 7 articles from 3 study populations were considered at moderate or high quality. The lack of standardisation of growth analysis methods prevented performing a meta-analysis. Overall, EPG was positively associated with neurodevelopmental outcome, especially Intelligence Quotient (IQ) when available. In this relationship, the first 6 months of life might be a critical period. Analysis of the few articles investigating the shape of the relationships revealed a non-linear association, with a plateau for IQ with higher weight gain, which suggests a possible ceiling effect. CONCLUSIONS: A positive association was generally found between EPG and neurodevelopmental outcome for individuals born MP or SGAT. Strategies for future epidemiological studies are suggested to improve the characterisation of this relationship.
Authors: Katie M Strobel; Tahmineh Romero; Katelin Kramer; Erika Fernandez; Catherine Rottkamp; Cherry Uy; Roberta Keller; Laurel Moyer; Francis Poulain; Jae H Kim; Daniel A DeUgarte; Kara L Calkins Journal: J Pediatr Date: 2021-02-26 Impact factor: 6.314
Authors: Anyir Hsieh; Sarah Tabbutt; Duan Xu; A James Barkovich; Steven Miller; Patrick McQuillen; Shabnam Peyvandi Journal: J Am Heart Assoc Date: 2019-05-21 Impact factor: 5.501
Authors: Meng Yuan Tian; Shi Wu Wen; Ravi Retnakaran; Hao Ren Wang; Shu Juan Ma; Meng Shi Chen; Xiao Lei Wang; Hui Jun Lin; Hong Zhuan Tan Journal: Sci Rep Date: 2020-11-05 Impact factor: 4.379