Manuela Nestola1, Nicoletta De Matthaeis2, Pietro Manuel Ferraro3, Paola Fuso4, Stefano Costanzi3, Gian Franco Zannoni5, Fabrizio Pizzolante2, Sabina Vasquez Quadra6, Giovanni Gambaro3, Gian Ludovico Rapaccini2. 1. Altamedica Artemisia, Viale Liegi 45, 00198, Rome, Italy. manuelanestola@gmail.com. 2. Gastroenterology Unit, Policlinico A. Gemelli, Catholic University, Largo Agostino Gemelli, 8, 00168, Rome, Italy. 3. Nephrology Unit, Policlinico A. Gemelli, Catholic University, Largo Agostino Gemelli, 8, 00168, Rome, Italy. 4. Department of Woman and Child Health, Policlinico A. Gemelli, Catholic University, Largo Agostino Gemelli, 8, 00168, Rome, Italy. 5. Pathology Unit, Policlinico A. Gemelli, Catholic University, Largo Agostino Gemelli, 8, 00168, Rome, Italy. 6. Radiology Unit, Policlinico A. Gemelli, Catholic University, Largo Agostino Gemelli, 8, 00168, Rome, Italy.
Abstract
PURPOSE: To compare contrast-enhanced ultrasonography (CEUS)-derived time-intensity (TI) curves with histological findings in kidneys of patients affected by chronic glomerulonephritides (GN) in the early stage of disease. METHODS: Research ethics committee approval and patient written informed consent were obtained. Thirty-one patients who showed clinical and laboratory signs of GN, with preserved renal function, were consecutively enrolled. They underwent kidney CEUS, from which TI curves were obtained, and kidney biopsy. TI curves were compared with clinical data, ultrasound (US) Doppler, and histological parameters. RESULTS: The persistence of contrast agent signal during the wash-out phase was found to be correlated with the degree of disease activity (p = 0.016) and in particular with the presence of mesangial hyperplasia (p = 0.008). No correlation was observed between TI curves and clinical or Doppler US-derived parameters. CONCLUSIONS: The persistence of contrast agent signal in the wash-out phase of CEUS appears to reflect a disturbance of perfusion in glomerular capillaries in the early stages of GN. We found that the histological element directly correlated with the prolonged wash-out was mesangial hyperplasia.
PURPOSE: To compare contrast-enhanced ultrasonography (CEUS)-derived time-intensity (TI) curves with histological findings in kidneys of patients affected by chronic glomerulonephritides (GN) in the early stage of disease. METHODS: Research ethics committee approval and patient written informed consent were obtained. Thirty-one patients who showed clinical and laboratory signs of GN, with preserved renal function, were consecutively enrolled. They underwent kidney CEUS, from which TI curves were obtained, and kidney biopsy. TI curves were compared with clinical data, ultrasound (US) Doppler, and histological parameters. RESULTS: The persistence of contrast agent signal during the wash-out phase was found to be correlated with the degree of disease activity (p = 0.016) and in particular with the presence of mesangial hyperplasia (p = 0.008). No correlation was observed between TI curves and clinical or Doppler US-derived parameters. CONCLUSIONS: The persistence of contrast agent signal in the wash-out phase of CEUS appears to reflect a disturbance of perfusion in glomerular capillaries in the early stages of GN. We found that the histological element directly correlated with the prolonged wash-out was mesangial hyperplasia.
Authors: F Piscaglia; C Nolsøe; C F Dietrich; D O Cosgrove; O H Gilja; M Bachmann Nielsen; T Albrecht; L Barozzi; M Bertolotto; O Catalano; M Claudon; D A Clevert; J M Correas; M D'Onofrio; F M Drudi; J Eyding; M Giovannini; M Hocke; A Ignee; E M Jung; A S Klauser; N Lassau; E Leen; G Mathis; A Saftoiu; G Seidel; P S Sidhu; G ter Haar; D Timmerman; H P Weskott Journal: Ultraschall Med Date: 2011-08-26 Impact factor: 6.548
Authors: Tim Leiner; Alphons G H Kessels; Patricia J Nelemans; G Boudewijn C Vasbinder; Michiel W de Haan; Peter E J H M Kitslaar; Kai Yiu J A M Ho; Jan H M Tordoir; Joseph M A van Engelshoven Journal: Radiology Date: 2005-05 Impact factor: 11.105
Authors: G L Rapaccini; M Pompili; R Orefice; M Covino; L Riccardi; A Cedrone; G Gasbarrini Journal: Scand J Gastroenterol Date: 2004-02 Impact factor: 2.423
Authors: M Pompili; L Riccardi; S Semeraro; R Orefice; F Elia; B Barbaro; M Covino; A Grieco; G Gasbarrini; G L Rapaccini Journal: Dig Liver Dis Date: 2007-12-04 Impact factor: 4.088
Authors: Francesco Maria Drudi; Vito Cantisani; Antonio Granata; Flavia Angelini; Daniela Messineo; Carlo De Felice; Evaristo Ettorre Journal: J Ultrasound Date: 2019-06-13