Leticia González-Blanco1, María Paz García-Portilla2, Leticia García-Álvarez3, Lorena de la Fuente-Tomás4, Celso Iglesias García5, Pilar A Sáiz2, Susana Rodríguez-González6, Ana Coto-Montes6, Julio Bobes2. 1. Área de Psiquiatría, Universidad de Oviedo, Oviedo, España; Servicio de Salud del Principado de Asturias, Oviedo, España; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, España. Electronic address: leticiagonzalezblanco@gmail.com. 2. Área de Psiquiatría, Universidad de Oviedo, Oviedo, España; Servicio de Salud del Principado de Asturias, Oviedo, España; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, España. 3. Área de Psiquiatría, Universidad de Oviedo, Oviedo, España; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, España. 4. Área de Psiquiatría, Universidad de Oviedo, Oviedo, España. 5. Área de Psiquiatría, Universidad de Oviedo, Oviedo, España; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, España; Servicio de Salud del Principado de Asturias, Langreo, España. 6. Departamento de Morfología y Biología Celular, Universidad de Oviedo, Oviedo, España.
Abstract
INTRODUCTION: Several studies have described increased oxidative stress parameters in patients with schizophrenia. The objectives of the current study were to identify potential oxidative stress biomarkers in stable patients during first 10 years of schizophrenia and determine if they are associated with specific clinical dimensions. MATERIAL AND METHODS: Seventy-three clinically stable outpatients with schizophrenia and 73 sex and age-matched healthy controls were recruited. Sociodemographic, clinical and biological data were collected at enrollment. Blood biomarkers included homocysteine, the percentage of hemolysis, lipid peroxidation subproducts, and as an antioxidant biomarker, catalase activity in erythrocytes. RESULTS: Comparative analyses after controlling for smoking and metabolic syndrome evidenced a significant increase in catalase activity in patients. Also, lower lipid peroxidation levels showed an association with negative symptoms. CONCLUSIONS: In conclusion, compensatory antioxidant mechanisms might be increased in stable patients with schizophrenia at early stages. Furthermore, there may be an inverse relationship between oxidative stress and negative dimension.
INTRODUCTION: Several studies have described increased oxidative stress parameters in patients with schizophrenia. The objectives of the current study were to identify potential oxidative stress biomarkers in stable patients during first 10 years of schizophrenia and determine if they are associated with specific clinical dimensions. MATERIAL AND METHODS: Seventy-three clinically stable outpatients with schizophrenia and 73 sex and age-matched healthy controls were recruited. Sociodemographic, clinical and biological data were collected at enrollment. Blood biomarkers included homocysteine, the percentage of hemolysis, lipid peroxidation subproducts, and as an antioxidant biomarker, catalase activity in erythrocytes. RESULTS: Comparative analyses after controlling for smoking and metabolic syndrome evidenced a significant increase in catalase activity in patients. Also, lower lipid peroxidation levels showed an association with negative symptoms. CONCLUSIONS: In conclusion, compensatory antioxidant mechanisms might be increased in stable patients with schizophrenia at early stages. Furthermore, there may be an inverse relationship between oxidative stress and negative dimension.