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Literature DB >> 2968834

Effect of intratracheal inoculation of Pasteurella haemolytica cytotoxin on the integrity of rat lung.

Abstract

This study was conducted to investigate the in vivo effect of a single intratracheal inoculation of Pasteurella haemolytica cytotoxin on the rat lung. Changes in the biochemical and cytological composition of bronchoalveolar lavage fluid were used to estimate the magnitude of pulmonary cell injury, inflammatory response, vascular permeability and functional status of pulmonary alveolar macrophages. Effect of treatment was compared with rats intratracheally inoculated with supernatants of Pasteurella multocida or with sterile physiological saline solution (vehicle). Results indicated that Pasteurella haemolytica supernatants were not significantly toxic for the lungs of rats.

Entities: Chemical Disease Species

Mesh：

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Year: 1987 PMID： 2968834 PMCID： PMC1255381

Source DB: PubMed Journal: Can J Vet Res ISSN： 0830-9000 Impact factor: 1.310

12 in total

1. Effect of vehicular volume on the early pulmonary injury and inflammatory response in rats inoculated intratracheally with silica.

Authors: A Lopez; S Yong; A Sharma; M Prior
Journal: Am J Vet Res Date: 1987-08 Impact factor: 1.156

2. The effect of quartz, administered by intratracheal instillation, on the rat lung. I. The cellular response.

Authors: A Morgan; S R Moores; A Holmes; J C Evans; N H Evans; A Black
Journal: Environ Res Date: 1980-06 Impact factor: 6.498

3. Cytotoxin of Pasteurella haemolytica acting on bovine leukocytes.

Authors: P E Shewen; B N Wilkie
Journal: Infect Immun Date: 1982-01 Impact factor: 3.441

4. Early damage indicators in the lung. V. Biochemical and cytological response to NO2 inhalation.

Authors: D B DeNicola; A H Rebar; R F Henderson
Journal: Toxicol Appl Pharmacol Date: 1981-09-15 Impact factor: 4.219

5. Evidence of species specificity in the cytocidal effects of Pasteurella haemolytica.

Authors: K L Kaehler; R J Markham; C C Muscoplat; D W Johnson
Journal: Infect Immun Date: 1980-11 Impact factor: 3.441

6. Lung damage induced by butylated hydroxytoluene in mice. Biochemical, cellular, and morphologic characterization.

Authors: L J Smith
Journal: Am Rev Respir Dis Date: 1984-11

7. Injury versus inflammatory response in the lungs of rats intratracheally inoculated with bacterial lipopolysaccharide.

Authors: A Lopez; S Yong
Journal: Am J Vet Res Date: 1986-06 Impact factor: 1.156

Effect of intratracheal inoculation of Pasteurella haemolytica cytotoxin on the integrity of rat lung.

1. Effect of vehicular volume on the early pulmonary injury and inflammatory response in rats inoculated intratracheally with silica.

2. The effect of quartz, administered by intratracheal instillation, on the rat lung. I. The cellular response.

3. Cytotoxin of Pasteurella haemolytica acting on bovine leukocytes.

4. Early damage indicators in the lung. V. Biochemical and cytological response to NO2 inhalation.

5. Evidence of species specificity in the cytocidal effects of Pasteurella haemolytica.

6. Lung damage induced by butylated hydroxytoluene in mice. Biochemical, cellular, and morphologic characterization.

7. Injury versus inflammatory response in the lungs of rats intratracheally inoculated with bacterial lipopolysaccharide.

8. Potential interactions between multiple etiologies and pathogenesis of experimental diseases.

Review 9. The role of toxicological interactions in lung injury.

Review 10. Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals.

Review 1. Pathogenesis and pathology of bovine pneumonia.