Literature DB >> 29688303

Free Fatty Acid Receptors in Enteroendocrine Cells.

Van B Lu1, Fiona M Gribble1, Frank Reimann1.   

Abstract

Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a variety of gut hormones. FFA1 and FFA4 are receptors for long-chain fatty acids that have been linked to the elevation of plasma gut hormones after fat ingestion. FFA2 and FFA3 are receptors for SCFA, which are generated at high concentrations by microbial fermentation of dietary fiber and have also been implicated in enhancement of gut hormone secretion. FFAs are candidate drug targets for increasing the secretion of intestinal hormones such as glucagon-like peptide-1 and peptide YY as potential new treatments for type 2 diabetes and obesity. This review will examine aspects of intestinal physiology and pharmacology related to the function of FFAs in enteroendocrine cells.

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Year:  2018        PMID： 29688303     DOI： 10.1210/en.2018-00261

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  14 in total

1.  Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.

Authors:  Medha Priyadarshini; Connor Cole; Gautham Oroskar; Anton E Ludvik; Barton Wicksteed; Congcong He; Brian T Layden
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-02-19       Impact factor: 3.619

2.  Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance.

Authors:  Joshua Wollam; Matthew Riopel; Yong-Jiang Xu; Andrew M F Johnson; Jachelle M Ofrecio; Wei Ying; Dalila El Ouarrat; Luisa S Chan; Andrew W Han; Nadir A Mahmood; Caitlin N Ryan; Yun Sok Lee; Jeramie D Watrous; Mahendra D Chordia; Dongfeng Pan; Mohit Jain; Jerrold M Olefsky
Journal:  Diabetes       Date:  2019-04-22       Impact factor: 9.461

3.  Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.

Authors:  Kristen R Lednovich; Chioma Nnyamah; Sophie Gough; Medha Priyadarshini; Kai Xu; Barton Wicksteed; Sidharth Mishra; Shalini Jain; Joseph L Zapater; Hariom Yadav; Brian T Layden
Journal:  Am J Physiol Endocrinol Metab       Date:  2022-07-20       Impact factor: 5.900

4.  Regulation of Enteroendocrine Cell Networks by the Major Human Gut Symbiont Bacteroides thetaiotaomicron.

Authors:  Amisha Modasia; Aimee Parker; Emily Jones; Regis Stentz; Arlaine Brion; Andrew Goldson; Marianne Defernez; Tom Wileman; L Ashley Blackshaw; Simon R Carding
Journal:  Front Microbiol       Date:  2020-11-06       Impact factor: 5.640

5.  Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet.

Authors:  Shigenobu Matsumura; Fuka Ishikawa; Tsutomu Sasaki; Mike Krogh Terkelsen; Kim Ravnskjaer; Tomoki Jinno; Jin Tanaka; Tsuyoshi Goto; Kazuo Inoue
Journal:  Endocrinology       Date:  2021-09-01       Impact factor: 4.736

6.  Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Authors:  Lihua Ye; Munhyung Bae; Chelsi D Cassilly; Sairam V Jabba; Daniel W Thorpe; Alyce M Martin; Hsiu-Yi Lu; Jinhu Wang; John D Thompson; Colin R Lickwar; Kenneth D Poss; Damien J Keating; Sven-Eric Jordt; Jon Clardy; Rodger A Liddle; John F Rawls
Journal:  Cell Host Microbe       Date:  2020-12-21       Impact factor: 21.023

7.  GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery.

Authors:  Gabriele Carullo; Sarah Mazzotta; Margarita Vega-Holm; Fernando Iglesias-Guerra; José Manuel Vega-Pérez; Francesca Aiello; Antonella Brizzi
Journal:  J Med Chem       Date:  2021-04-10       Impact factor: 7.446

Review 8.  The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders.

Authors:  Paul Richards; Nancy A Thornberry; Shirly Pinto
Journal:  Mol Metab       Date:  2021-02-03       Impact factor: 7.422

9.  FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells.

Authors:  Estela Lorza-Gil; Gabriele Kaiser; Elisabeth Rexen Ulven; Gabriele M König; Felicia Gerst; Morgana Barroso Oquendo; Andreas L Birkenfeld; Hans-Ulrich Häring; Evi Kostenis; Trond Ulven; Susanne Ullrich
Journal:  Sci Rep       Date:  2020-10-05       Impact factor: 4.379

Review 10.  The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates.

Authors:  Jocelijn Meijerink
Journal:  Molecules       Date:  2021-03-05       Impact factor: 4.411
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