Literature DB >> 2968829

Dehydroepiandrosterone sulfate improves memory in aging mice.

J F Flood1, E Roberts.   

Abstract

Middle-aged (18 month old) and old (24 month old) mice showed poorer retention of footshock active avoidance training (FAAT) than young mice (2 month old). Immediate post-training subcutaneous injection of dehydroepiandrosterone sulfate (DHEAS) improved retention of FAAT in middle-aged and old mice to the high levels observed in young mice. DHEAS, a major naturally occurring adrenal steroid that decreases in blood serum with age, could be rate-limiting in achievement of retention of learning.

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Year:  1988        PMID： 2968829     DOI： 10.1016/0006-8993(88)91116-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  28 in total

1.  Neurosteroid transport by the organic solute transporter OSTα-OSTβ.

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2.  Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.

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3.  Hormone supplementation during aging: how much and when?

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4.  PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats.

Authors:  David S Gelinas; JoAnne McLaurin
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5.  Perimenopausal regulation of steroidogenesis in the nonhuman primate.

Authors:  Krystina G Sorwell; Steven G Kohama; Henryk F Urbanski
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Review 6.  The cerebellum as a target for estrogen action.

Authors:  Valerie L Hedges; Timothy J Ebner; Robert L Meisel; Paul G Mermelstein
Journal:  Front Neuroendocrinol       Date:  2012-09-05       Impact factor: 8.606

7.  Sigma receptors [σRs]: biology in normal and diseased states.

Authors:  Colin G Rousseaux; Stephanie F Greene
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8.  Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive.

Authors:  J F Flood; J E Morley; E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

9.  Dehydroepiandrosterone sulfate and cognitive function in the elderly: The InCHIANTI Study.

Authors:  G Valenti; L Ferrucci; F Lauretani; G Ceresini; S Bandinelli; M Luci; G Ceda; M Maggio; R S Schwartz
Journal:  J Endocrinol Invest       Date:  2009-10       Impact factor: 4.256

Review 10.  Dehydroepiandrosterone and age-related cognitive decline.

Authors:  Krystina G Sorwell; Henryk F Urbanski
Journal:  Age (Dordr)       Date:  2009-08-27
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