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Literature DB >> 29687890

Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis.

Abstract

Several proteins have been implicated in fatty acid (FA) transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1) a member of the CD36 family and the FA transport protein 4 (FATP4). Here, we review the regulation of enterocyte FA uptake and its function in lipid absorption including prechylomicron formation, assembly and transport. Emphasis is given to CD36, which is abundantly expressed along the digestive tract of rodents and humans and has been the most studied. We also address the pleiotropic functions of CD36 that go beyond lipid absorption and metabolism to include recent evidence of its impact on intestinal homeostasis and barrier maintenance. Areas of progress involving contribution of membrane phospholipid remodeling and of cytosolic FA-binding proteins, FABP1 and FABP2 to fat absorption will be covered. © 2018 American Physiological Society. Compr Physiol 8:493-507, 2018.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2018 PMID： 29687890 PMCID： PMC6247794 DOI： 10.1002/cphy.c170026

Source DB: PubMed Journal: Compr Physiol ISSN： 2040-4603 Impact factor: 9.090

176 in total

Review 1. Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.

Authors: D E Greenwalt; R H Lipsky; C F Ockenhouse; H Ikeda; N N Tandon; G A Jamieson
Journal: Blood Date: 1992-09-01 Impact factor: 22.113

2. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue.

Authors: Christina S-Y Chen; Elias M Bench; Timothy D Allerton; Allyson L Schreiber; Kenneth P Arceneaux; Stefany D Primeaux
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2013-10-23 Impact factor: 3.619

3. Genetic and morphological analyses reveal a critical interaction between the C-termini of two SNARE proteins and a parallel four helical arrangement for the exocytic SNARE complex.

Authors: L Katz; P I Hanson; J E Heuser; P Brennwald
Journal: EMBO J Date: 1998-11-02 Impact factor: 11.598

4. Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol.

Authors: Ariëtte van Bennekum; Moritz Werder; Stephen T Thuahnai; Chang-Hoon Han; Phu Duong; David L Williams; Philipp Wettstein; Georg Schulthess; Michael C Phillips; Helmut Hauser
Journal: Biochemistry Date: 2005-03-22 Impact factor: 3.162

5. Fatty acid transfer from liver and intestinal fatty acid-binding proteins to membranes occurs by different mechanisms.

Authors: K T Hsu; J Storch
Journal: J Biol Chem Date: 1996-06-07 Impact factor: 5.157

Review 6. Control of chylomicron export from the intestine.

Authors: Charles M Mansbach; Shahzad Siddiqi
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2016-02-25 Impact factor: 4.052

Review 7. Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins.

Authors: Robert Ehehalt; Joachim Füllekrug; Jürgen Pohl; Axel Ring; Thomas Herrmann; Wolfgang Stremmel
Journal: Mol Cell Biochem Date: 2006-02-14 Impact factor: 3.396

8. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

Authors: Eric D Labonté; Lisa M Camarota; Juan C Rojas; Ronald J Jandacek; Dean E Gilham; Joanna P Davies; Yiannis A Ioannou; Patrick Tso; David Y Hui; Philip N Howles
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2008-08-21 Impact factor: 4.052

9. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.

Authors: Fatiha Nassir; Brody Wilson; Xianlin Han; Richard W Gross; Nada A Abumrad
Journal: J Biol Chem Date: 2007-05-15 Impact factor: 5.157

10. Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.

Authors: Sascha Obrowsky; Prakash G Chandak; Jay V Patankar; Silvia Povoden; Stefanie Schlager; Erin E Kershaw; Juliane G Bogner-Strauss; Gerald Hoefler; Sanja Levak-Frank; Dagmar Kratky
Journal: J Lipid Res Date: 2012-12-06 Impact factor: 5.922

23 in total

1. Assembly and Characterization of Biocompatible Coenzyme Q₁₀ -Enriched Lipid Nanoparticles.

Authors: Anthony Moschetti; Lucas N Vine; Kyle Lethcoe; Ruben K Dagda; Patricia Ellison; Robert O Ryan
Journal: Lipids Date: 2020-02-19 Impact factor: 1.880

Review 2. A nexus of lipid and O-Glcnac metabolism in physiology and disease.

Authors: Amber Lockridge; John A Hanover
Journal: Front Endocrinol (Lausanne) Date: 2022-08-30 Impact factor: 6.055

3. Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis.

Authors: Jing Cheng; Jianhua Zhai; Weilong Zhong; Jingwen Zhao; Lu Zhou; Bangmao Wang
Journal: Calcif Tissue Int Date: 2022-05-26 Impact factor: 4.000

Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis.

Review 1. Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.

2. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue.

3. Genetic and morphological analyses reveal a critical interaction between the C-termini of two SNARE proteins and a parallel four helical arrangement for the exocytic SNARE complex.

4. Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol.

5. Fatty acid transfer from liver and intestinal fatty acid-binding proteins to membranes occurs by different mechanisms.

Review 6. Control of chylomicron export from the intestine.

Review 7. Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins.

8. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

9. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.

10. Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.

1. Assembly and Characterization of Biocompatible Coenzyme Q₁₀ -Enriched Lipid Nanoparticles.

Review 2. A nexus of lipid and O-Glcnac metabolism in physiology and disease.

3. Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis.

4. A Modern Approach to Dyslipidemia.

Review 5. Carotenoid metabolism at the intestinal barrier.

Review 6. The Intestinal Lymphatic System: Functions and Metabolic Implications.

7. Effect of Microbial Status on Hepatic Odd-Chain Fatty Acids Is Diet-Dependent.

Review 8. Molecular components affecting ocular carotenoid and retinoid homeostasis.

9. Advanced glycation end products and their receptors in serum of patients with type 2 diabetes.

10. Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.