Literature DB >> 29687124

A protein structure-guided covalent scaffold selectively targets the B1 and B2 subclass metallo-β-lactamases.

Cheng Chen1, Yang Xiang, Ke-Wu Yang, Yuejuan Zhang, Wen-Ming Wang, Jian-Peng Su, Ying Ge, Ya Liu.   

Abstract

We report the discovery of ebselen-based dual covalent inhibitors of metallo-β-lactamases. Fluorescence and MALDI-TOF analysis suggested that the scaffold could bind to NDM-1 by forming a S-Se bond with Cys221 and an amide bond with Lys224 of NDM-1, thereby exhibiting selective inhibition and labeling against B1 and B2 subclass enzymes in vitro and in vivo.

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Year:  2018        PMID： 29687124     DOI： 10.1039/c8cc01067f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  meta-Substituted benzenesulfonamide: a potent scaffold for the development of metallo-β-lactamase ImiS inhibitors.

Authors:  Ya Liu; Cheng Chen; Le-Yun Sun; Han Gao; Jian-Bin Zhen; Ke-Wu Yang
Journal:  RSC Med Chem       Date:  2020-01-10

Review 2.  Metallo-β-lactamases and a tug-of-war for the available zinc at the host-pathogen interface.

Authors:  Guillermo Bahr; Lisandro J González; Alejandro J Vila
Journal:  Curr Opin Chem Biol       Date:  2021-12-02       Impact factor: 8.822

3.  Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor.

Authors:  Yang Xiang; Yue-Juan Zhang; Ying Ge; Yajun Zhou; Cheng Chen; Weixiao Yuan Wahlgren; Xiangshi Tan; Xi Chen; Ke-Wu Yang
Journal:  Biomolecules       Date:  2020-01-01

4.  Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe.

Authors:  Radhika Mehta; Dann D Rivera; David J Reilley; Dominique Tan; Pei W Thomas; Abigail Hinojosa; Alesha C Stewart; Zishuo Cheng; Caitlyn A Thomas; Michael W Crowder; Anastassia N Alexandrova; Walter Fast; Emily L Que
Journal:  J Am Chem Soc       Date:  2021-05-26       Impact factor: 16.383

5.  Discovery of the Novel Inhibitor Against New Delhi Metallo-β-Lactamase Based on Virtual Screening and Molecular Modelling.

Authors:  Xiyan Wang; Yanan Yang; Yawen Gao; Xiaodi Niu
Journal:  Int J Mol Sci       Date:  2020-05-18       Impact factor: 5.923

Review 6.  Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism.

Authors:  Antonella R Palacios; María-Agustina Rossi; Graciela S Mahler; Alejandro J Vila
Journal:  Biomolecules       Date:  2020-06-03

Review 7.  β-Lactamases and β-Lactamase Inhibitors in the 21st Century.

Authors:  Catherine L Tooke; Philip Hinchliffe; Eilis C Bragginton; Charlotte K Colenso; Viivi H A Hirvonen; Yuiko Takebayashi; James Spencer
Journal:  J Mol Biol       Date:  2019-04-05       Impact factor: 5.469

8.  Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators.

Authors:  Ruo-Xin Li; Rui Han; Guo-Jie Wu; Fu-She Han; Jin-Ming Gao
Journal:  Mar Drugs       Date:  2020-06-11       Impact factor: 5.118

9.  Elusive structural changes of New Delhi metallo-β-lactamase revealed by ultraviolet photodissociation mass spectrometry.

Authors:  M Rachel Mehaffey; Yeong-Chan Ahn; Dann D Rivera; Pei W Thomas; Zishuo Cheng; Michael W Crowder; R F Pratt; Walter Fast; Jennifer S Brodbelt
Journal:  Chem Sci       Date:  2020-08-11       Impact factor: 9.969

Review 10.  Emerging Strategies to Combat β-Lactamase Producing ESKAPE Pathogens.

Authors:  Corneliu Ovidiu Vrancianu; Irina Gheorghe; Elena-Georgiana Dobre; Ilda Czobor Barbu; Roxana Elena Cristian; Marcela Popa; Sang Hee Lee; Carmen Limban; Ilinca Margareta Vlad; Mariana Carmen Chifiriuc
Journal:  Int J Mol Sci       Date:  2020-11-12       Impact factor: 6.208
  10 in total

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