Sunil W Dutta1, Tasneem A Kaleem2, Donald A Muller3, Jennifer Peterson4, Anna C Harrell2, Alfredo Quinones-Hinojosa5, Daniel M Trifiletti4. 1. Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA. 2. Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, USA. 3. Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA. Electronic address: trifiletti.daniel@mayo.edu. 4. Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, USA; Department of Neurological Surgery, Mayo Clinic, Jacksonville, FL, USA. 5. Department of Neurological Surgery, Mayo Clinic, Jacksonville, FL, USA.
Abstract
PURPOSE: To investigate clinical characteristics and patterns of care among patients with central neurocytomas in a large cohort of patients. METHODS: The National Cancer Database (NCDB) was queried to identify patients with biopsy confirmed neurocytoma from 2004 to 2015. Patterns of care were described and univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival. RESULTS: Among 223,404 patients with brain tumors in the NCDB, 868 patients were diagnosed with biopsy-proven neurocytoma and analyzed (0.4% or approximately 75 patients annually). Median age at diagnosis was 31 years and median tumor size was 4-5 cm. Diagnosis was similar between male (49.5%) and female (50.5%). Regarding location, 622 (72%) tumors were intraventricular, 168 (19%) were extra-ventricular, and 78 (9%) overlapping or unspecified. Five-year overall survival among all patients was 89%. On multivariable analysis tumor location, extent of resection, and use of radiation, were not predictive for improved survival (each p > 0.05); however, patient age (p < 0.001), WHO grade (p < 0.001), and medical comorbidity scores (p = 0.002) were independently associated with overall survival. CONCLUSION: Patients with central neurocytoma often present as young adults with sizable tumor burden and are well managed with surgery alone. Considering their favorable survival, efforts to improve tumor control should be carefully weighed against the long-term risks associated with adjuvant therapy like radiation.
PURPOSE: To investigate clinical characteristics and patterns of care among patients with central neurocytomas in a large cohort of patients. METHODS: The National Cancer Database (NCDB) was queried to identify patients with biopsy confirmed neurocytoma from 2004 to 2015. Patterns of care were described and univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival. RESULTS: Among 223,404 patients with brain tumors in the NCDB, 868 patients were diagnosed with biopsy-proven neurocytoma and analyzed (0.4% or approximately 75 patients annually). Median age at diagnosis was 31 years and median tumor size was 4-5 cm. Diagnosis was similar between male (49.5%) and female (50.5%). Regarding location, 622 (72%) tumors were intraventricular, 168 (19%) were extra-ventricular, and 78 (9%) overlapping or unspecified. Five-year overall survival among all patients was 89%. On multivariable analysis tumor location, extent of resection, and use of radiation, were not predictive for improved survival (each p > 0.05); however, patient age (p < 0.001), WHO grade (p < 0.001), and medical comorbidity scores (p = 0.002) were independently associated with overall survival. CONCLUSION:Patients with central neurocytoma often present as young adults with sizable tumor burden and are well managed with surgery alone. Considering their favorable survival, efforts to improve tumor control should be carefully weighed against the long-term risks associated with adjuvant therapy like radiation.
Authors: Joonho Byun; Seok Ho Hong; Min Jae Yoon; Sae Min Kwon; Young Hyun Cho; Jeong Hoon Kim; Chang Jin Kim Journal: J Neurooncol Date: 2018-09-17 Impact factor: 4.130
Authors: Claudia Gaggiotti; Giuseppe Roberto Giammalva; Marco Raimondi; Ada Maria Florena; Rosa Maria Gerardi; Francesca Graziano; Silvana Tumbiolo; Domenico Gerardo Iacopino; Rosario Maugeri Journal: Surg Neurol Int Date: 2021-03-08
Authors: A Kaywan Aftahy; Melanie Barz; Philipp Krauss; Friederike Liesche; Benedikt Wiestler; Stephanie E Combs; Christoph Straube; Bernhard Meyer; Jens Gempt Journal: BMC Cancer Date: 2020-11-03 Impact factor: 4.430