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Literature DB >> 29685

Sulphasalazine is a potent inhibitor of prostaglandin 15-hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis.

Abstract

Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15-hydroxydehydrogenase in rabbit colon (ID50 = 50 micrometer) and in several other organs of different species, but does not inhibit prostaglandin delta-13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.

Entities: Chemical Disease Species

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Year: 1978 PMID： 29685 PMCID： PMC1668267 DOI： 10.1111/j.1476-5381.1978.tb08633.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

14 in total

1. Effect of carbenoxolone on prostaglandin synthesis and degradation.

Authors: B M Peskar; A Holland; B A Peskar
Journal: J Pharm Pharmacol Date: 1976-02 Impact factor: 3.765

Review 2. Prostaglandins as factors in diseases of the alimentary tract.

Authors: A Bennett
Journal: Adv Prostaglandin Thromboxane Res Date: 1976

3. PREDNISONE AS MAINTENANCE TREATMENT FOR ULCERATIVE COLITIS IN REMISSION.

Authors: J E LENNARD-JONES; J J MISIEWICZ; A M CONNELL; J H BARON; F A JONES
Journal: Lancet Date: 1965-01-23 Impact factor: 79.321

Review 4. Drug therapy: Sulfasalazine.

Authors: P Goldman; M A Peppercorn
Journal: N Engl J Med Date: 1975-07-03 Impact factor: 91.245

5. Prostaglandin E in peptic ulcer disease.

Authors: J G Hinsdale; J J Engel; D E Wilson
Journal: Prostaglandins Date: 1974-06-25

6. Inhibition of indomethacin-induced gastric ulceration in the rat by perorally-administered synthetic and natural prostaglandin analogues.

Authors: W Lippmann
Journal: Prostaglandins Date: 1974-07-10

4. Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats.

Authors: Michael W Whitehouse
Journal: Inflammopharmacology Date: 2005 Impact factor: 4.473

Sulphasalazine is a potent inhibitor of prostaglandin 15-hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis.

1. Effect of carbenoxolone on prostaglandin synthesis and degradation.

Review 2. Prostaglandins as factors in diseases of the alimentary tract.

3. PREDNISONE AS MAINTENANCE TREATMENT FOR ULCERATIVE COLITIS IN REMISSION.

Review 4. Drug therapy: Sulfasalazine.

5. Prostaglandin E in peptic ulcer disease.

6. Inhibition of indomethacin-induced gastric ulceration in the rat by perorally-administered synthetic and natural prostaglandin analogues.

7. The effects of anti-ulcer agents on indomethacin-induced gastric ulceration in the rat.

8. An extended study of indomethacin. I. Clinical pharmacology.

9. Drugs which inhibit prostaglandin biosynthesis.

10. Pathways of prostaglandin F2alpha metabolism in mammalian kidneys.

Review 1. Sulfasalazine. Multiplicity of action.

Review 2. Inflammatory intermediaries in inflammatory bowel disease.

3. Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

4. Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats.

Review 5. Prostaglandins and ulcerative colitis.

6. Analgesic ingestion and other factors preceding relapse in ulcerative colitis.

7. Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease.

8. Modulation of human colonic arachidonic acid metabolism by sulfasalazine.

9. Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs.

10. Inhibition of leucocyte motility by drugs used in ulcerative colitis.