Hee-Yeon Choi1, Ga Eun Kim2, Kyoung Ae Kong3, Yu Jin Lee4, Weon-Jeong Lim5, So-Hyun Park6, Su Hee Ha7, Soo In Kim8. 1. Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: yeon8125@naver.com. 2. Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea; Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea. Electronic address: kim_psyche@daum.net. 3. Department of Preventive Medicine, School of Medicine, Ewha Womans University, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: kkong@ewha.ac.kr. 4. Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Electronic address: ewpsyche@snu.ac.kr. 5. Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: psyweon@ewha.ac.kr. 6. Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: park_psyche@daum.net. 7. Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: hsh88@nate.com. 8. Department of Psychiatry, Ewha Womans University College of medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Republic of Korea. Electronic address: 72sooik@ewha.ac.kr.
Abstract
INTRODUCTION: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. METHODS: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404). RESULTS: Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt. LIMITATIONS: The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA. CONCLUSIONS: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype.
INTRODUCTION: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorderpatients in Korea. METHODS: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404). RESULTS:Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt. LIMITATIONS: The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA. CONCLUSIONS: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMTrs4680 Met/Met genotype.
Authors: Alma Delia Genis-Mendoza; Yazmín Hernández-Díaz; Thelma Beatriz González-Castro; Carlos Alfonso Tovilla-Zárate; Rosa Giannina Castillo-Avila; María Lilia López-Narváez; Miguel Ángel Ramos-Méndez; Humberto Nicolini Journal: Front Psychiatry Date: 2022-07-19 Impact factor: 5.435
Authors: Patryk Rodek; Małgorzata Kowalczyk; Jan Kowalski; Aleksander Owczarek; Piotr Choręza; Krzysztof Kucia Journal: J Clin Med Date: 2022-10-07 Impact factor: 4.964