Zaizai Cao1, Ziyue Li1, Haijie Xiang1, Saiyu Huang1, Jinjian Gao1, Xiang Zhan1, Xiuxiu Zheng1, Bangliang Li1, JianBin Wu1, Bobei Chen2. 1. Department of Otolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. 2. Department of Otolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: wzbobei@outlook.com.
Abstract
BACKGROUND: Complete blood count (CBC) is an important blood test in clinical practice, and it has been recently used to predict the prognosis of patients with sudden sensorineural hearing loss (SSNHL). Some haematological indices of the CBC test have been reported to be associated with the clinical outcome of SSNHL. However, the prognostic value of these haematological indices in SSNHL is currently under debate. Here, we performed a meta-analysis to investigate the association between haematological indices of the CBC test and clinical outcomes in patients with SSNHL. METHODS: We conducted a meta-analysis of studies that evaluated the association between haematological indices and prognoses in patients with sudden hearing loss. Subgroup and sensitivity analyses were also performed to explore potential sources of heterogeneity. RESULTS: Ten studies that included 972 individuals were identified. Pooled analysis showed neutrophil-to-lymphocyte ratio (NLR) (weighted mean difference [WMD] = -1.69 and p < 0.001), platelet-to-lymphocyte ratio (PLR) (WMD = -38.45 and p < 0.001), neutrophil count (WMD = -1.57 × 109/L and p < 0.001) and lymphocyte count (WMD = 0.41 × 109/L and p < 0.001) to be the factors associated with the prognosis of SSNHL. CONCLUSIONS: Our findings indicated that NLR, PLR, neutrophil count and lymphocyte count are strongly associated with the prognosis of SSNHL. These four indices could be recommended as inexpensive markers to report treatment outcomes.
BACKGROUND: Complete blood count (CBC) is an important blood test in clinical practice, and it has been recently used to predict the prognosis of patients with sudden sensorineural hearing loss (SSNHL). Some haematological indices of the CBC test have been reported to be associated with the clinical outcome of SSNHL. However, the prognostic value of these haematological indices in SSNHL is currently under debate. Here, we performed a meta-analysis to investigate the association between haematological indices of the CBC test and clinical outcomes in patients with SSNHL. METHODS: We conducted a meta-analysis of studies that evaluated the association between haematological indices and prognoses in patients with sudden hearing loss. Subgroup and sensitivity analyses were also performed to explore potential sources of heterogeneity. RESULTS: Ten studies that included 972 individuals were identified. Pooled analysis showed neutrophil-to-lymphocyte ratio (NLR) (weighted mean difference [WMD] = -1.69 and p < 0.001), platelet-to-lymphocyte ratio (PLR) (WMD = -38.45 and p < 0.001), neutrophil count (WMD = -1.57 × 109/L and p < 0.001) and lymphocyte count (WMD = 0.41 × 109/L and p < 0.001) to be the factors associated with the prognosis of SSNHL. CONCLUSIONS: Our findings indicated that NLR, PLR, neutrophil count and lymphocyte count are strongly associated with the prognosis of SSNHL. These four indices could be recommended as inexpensive markers to report treatment outcomes.
Authors: Keon Vin Park; Kyoung Ho Oh; Yong Jun Jeong; Jihye Rhee; Mun Soo Han; Sung Won Han; June Choi Journal: Clin Exp Otorhinolaryngol Date: 2020-03-12 Impact factor: 3.372