S D Nelen1, K Bosscha2, V E P P Lemmens3,4, H H Hartgrink5, R H A Verhoeven3, J H W de Wilt1. 1. Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands. 2. Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands. 3. Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands. 4. Department of Public Health, Erasmus University Medical Centre, Rotterdam, The Netherlands. 5. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
Abstract
BACKGROUND: This study investigated age-related differences in surgically treated patients with gastric cancer, and aimed to identify factors associated with outcome. METHODS: Data from the Dutch Upper Gastrointestinal Cancer Audit were used. All patients with non-cardia gastric cancer registered between 2011 and 2015 who underwent surgery were selected. Patients were analysed by age group (less than 70 years versus 70 years or more). Multivariable logistic regression was used to assess the influence of clinicopathological factors on morbidity and mortality. RESULTS: A total of 1109 patients younger than 70 years and 1206 aged 70 years or more were included. Patients aged at least 70 years had more perioperative or postoperative complications (41·2 versus 32·5 per cent; P < 0·001) and a higher 30-day mortality rate (7·9 versus 3·2 per cent; P < 0·001) than those younger than 70 years. In multivariable analysis, age 70 years or more was associated with a higher risk of complications (odds ratio 1·29, 95 per cent c.i. 1·05 to 1·59). Postoperative mortality was not significantly associated with age. In the entire cohort, morbidity and mortality were influenced most by ASA grade, neoadjuvant chemotherapy and type of resection. CONCLUSION: ASA grade, neoadjuvant chemotherapy and type of resection are independent predictors of morbidity and death in patients with gastric cancer, irrespective of age.
BACKGROUND: This study investigated age-related differences in surgically treated patients with gastric cancer, and aimed to identify factors associated with outcome. METHODS: Data from the Dutch Upper Gastrointestinal Cancer Audit were used. All patients with non-cardia gastric cancer registered between 2011 and 2015 who underwent surgery were selected. Patients were analysed by age group (less than 70 years versus 70 years or more). Multivariable logistic regression was used to assess the influence of clinicopathological factors on morbidity and mortality. RESULTS: A total of 1109 patients younger than 70 years and 1206 aged 70 years or more were included. Patients aged at least 70 years had more perioperative or postoperative complications (41·2 versus 32·5 per cent; P < 0·001) and a higher 30-day mortality rate (7·9 versus 3·2 per cent; P < 0·001) than those younger than 70 years. In multivariable analysis, age 70 years or more was associated with a higher risk of complications (odds ratio 1·29, 95 per cent c.i. 1·05 to 1·59). Postoperative mortality was not significantly associated with age. In the entire cohort, morbidity and mortality were influenced most by ASA grade, neoadjuvant chemotherapy and type of resection. CONCLUSION:ASA grade, neoadjuvant chemotherapy and type of resection are independent predictors of morbidity and death in patients with gastric cancer, irrespective of age.
Authors: I Mokadem; W P M Dijksterhuis; M van Putten; L Heuthorst; J M de Vos-Geelen; N Haj Mohammad; G A P Nieuwenhuijzen; H W M van Laarhoven; R H A Verhoeven Journal: Gastric Cancer Date: 2019-04-04 Impact factor: 7.370
Authors: Thaís T T Tweed; Arjen van der Veen; Stan Tummers; David P J van Dijk; Misha D P Luyer; Jelle P Ruurda; Richard van Hillegersberg; Jan H M B Stoot; Juul J W Tegels; Karel W E Hulsewe; Hylke J F Brenkman; Maarten F J Seesing; Grard A P Nieuwenhuijzen; Jeroen E H Ponten; Bas P L Wijnhoven; Sjoerd M Lagarde; Wobbe O de Steur; Henk H Hartgrink; Ewout A Kouwenhoven; Marc J van Det; Eelco B Wassenaar; Edwin S van der Zaag; Werner A Draaisma; Ivo A M J Broeders; Suzanne S Gisbertz; Mark I van Berge Henegouwen; Hanneke W M van Laarhoven Journal: J Gastrointest Surg Date: 2022-04-29 Impact factor: 3.267
Authors: David Uihwan Lee; Gregory Hongyuan Fan; Kevin Chang; Ki Jung Lee; John Han; Daniel Jung; Jean Kwon; Raffi Karagozian Journal: J Gastric Cancer Date: 2022-07 Impact factor: 3.197