Rika Eguchi1,2, Daisuke Onozuka3, Kouji Ikeda4, Kenji Kuroda4, Ichiro Ieiri5, Akihito Hagihara6. 1. Department of Health Services Management and Policy, Kyushu University Graduate School of Medicine, Higashi-ku, Fukuoka, 812-8582, Japan. 2. Department of Clinical Pharmacokinetics, Kyushu University Graduate School of Pharmaceutical Science, Higashi-ku, Fukuoka, 812-8582, Japan. 3. Department of Health Services Management and Policy, Kyushu University Graduate School of Medicine, Higashi-ku, Fukuoka, 812-8582, Japan. onozukad@hcam.med.kyushu-u.ac.jp. 4. Hannan Hospital, 277 Handaminamino-cho, Naka-ku, Sakai, Osaka, 599-8263, Japan. 5. Department of Clinical Pharmacokinetics, Kyushu University Graduate School of Pharmaceutical Science, Higashi-ku, Fukuoka, 812-8582, Japan. ieiri-ttr@umin.ac.jp. 6. Department of Health Services Management and Policy, Kyushu University Graduate School of Medicine, Higashi-ku, Fukuoka, 812-8582, Japan. hagihara@hsmp.med.kyushu-u.ac.jp.
Abstract
PURPOSE: Although particulate matter (PM) is reported to affect the rate of emergency admissions for schizophrenia, no study has examined the relationship between particulate matter less than 2.5 μm in diameter (PM2.5) and the severity of schizophrenia. METHODS: We obtained data on patients with schizophrenia at a psychiatric hospital, and on air pollution in Sakai, Japan between Feb 1, 2013 and April 30, 2016. Multivariate logistic regression analyses were used to estimate the relationship between PM2.5 concentrations and scores on the Brief Psychiatric Rating Scale (BPRS) of schizophrenia patients at admission, with a lag of up to 7 days. RESULTS: During the study period, there were 1193 schizophrenia cases. The odds ratio (OR) for a BPRS score ≥ 50 at admission was 1.05 [95% confidence interval 1.00-1.10] and the effect of PM2.5 concentration was significant for lag period of 2 days. The ORs associated with PM2.5 concentration increased substantially for patients over 65 years of age. CONCLUSIONS: Ambient PM2.5 concentration was associated with exacerbation of schizophrenia. Our results suggest that protection for several days should be considered for controlling PM2.5-related schizophrenia, especially among elderly patients.
PURPOSE: Although particulate matter (PM) is reported to affect the rate of emergency admissions for schizophrenia, no study has examined the relationship between particulate matter less than 2.5 μm in diameter (PM2.5) and the severity of schizophrenia. METHODS: We obtained data on patients with schizophrenia at a psychiatric hospital, and on air pollution in Sakai, Japan between Feb 1, 2013 and April 30, 2016. Multivariate logistic regression analyses were used to estimate the relationship between PM2.5 concentrations and scores on the Brief Psychiatric Rating Scale (BPRS) of schizophreniapatients at admission, with a lag of up to 7 days. RESULTS: During the study period, there were 1193 schizophrenia cases. The odds ratio (OR) for a BPRS score ≥ 50 at admission was 1.05 [95% confidence interval 1.00-1.10] and the effect of PM2.5 concentration was significant for lag period of 2 days. The ORs associated with PM2.5 concentration increased substantially for patients over 65 years of age. CONCLUSIONS: Ambient PM2.5 concentration was associated with exacerbation of schizophrenia. Our results suggest that protection for several days should be considered for controlling PM2.5-related schizophrenia, especially among elderly patients.
Entities:
Keywords:
BPRS; Lag effect; PM2.5; Psychiatric severity; Schizophrenia
Authors: Youn-Hee Lim; Ho Kim; Jin Hee Kim; Sanghyuk Bae; Hye Yin Park; Yun-Chul Hong Journal: Environ Health Perspect Date: 2012-04-18 Impact factor: 9.031
Authors: F Bernardini; L Attademo; R Trezzi; C Gobbicchi; P M Balducci; V Del Bello; G Menculini; L Pauselli; M Piselli; T Sciarma; P Moretti; A Tamantini; R Quartesan; M T Compton; A Tortorella Journal: Epidemiol Psychiatr Sci Date: 2019-11-06 Impact factor: 6.892