Sucharat Limsitthichaikoon1, Bhattaranitch Khampaenjiraroch1, Teerasak Damrongrungruang2, Wanwisa Limphirat3, Suthasinee Thapphasaraphong4, Aroonsri Priprem5. 1. The Graduate School, Khon Kaen University, 123 Mittraphap Rd, Khon Kaen 40002, Thailand. 2. Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, 123 Mittraphap Rd, Khon Kaen 40002, Thailand. 3. Research Division, Synchrotron Light Research Institute, 111 University Avenue, Muang, Nakhon Ratchasima, 30000, Thailand. 4. Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Science, Khon Kaen University, 123 Mittraphap Rd, Khon Kaen, 40002, Thailand. 5. Division of Pharmaceutical Technology, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Abstract
AIM: An anthocyanin complex (AC), combined Zea mays and Clitoria ternatea extracts, was evaluated for topical oral wound healing in rats and a clinical trial in orthodontic patients. METHODS/ RESULTS: AC enhanced anthocyanin permeation in vitro. In rats, 10% w/w of AC in a mucoadhesive gel (AG) reduced erythema and sizes of oral wounds after topical applications at higher extent than its placebo gel. Acute orthodontic wounds in 68 volunteers were randomly assigned to topically receive either AG or placebo gel and double-blind assessed. Wound size reduction and wound closure enhancement were obvious in AG-treated group on day 3 (p < 0.05). CONCLUSION: At 10% w/w, AC promoted wound closure and possessed a potential in healing stimulation of acute oral wounds.
RCT Entities:
AIM: An anthocyanin complex (AC), combined Zea mays and Clitoria ternatea extracts, was evaluated for topical oral wound healing in rats and a clinical trial in orthodontic patients. METHODS/ RESULTS:AC enhanced anthocyanin permeation in vitro. In rats, 10% w/w of AC in a mucoadhesive gel (AG) reduced erythema and sizes of oral wounds after topical applications at higher extent than its placebo gel. Acute orthodontic wounds in 68 volunteers were randomly assigned to topically receive either AG or placebo gel and double-blind assessed. Wound size reduction and wound closure enhancement were obvious in AG-treated group on day 3 (p < 0.05). CONCLUSION: At 10% w/w, AC promoted wound closure and possessed a potential in healing stimulation of acute oral wounds.