Isabel Cristina Ribas Werlang1,2, Monique Cabral Hahn1,2, Juliana Rombaldi Bernardi1,2,3, Martha Nast4,5, Marcelo Zubaran Goldani1,2,6, Mariana Bohns Michalowski1,6. 1. a Laboratório de Pediatria Translacional/Núcleo de Estudos em Saúde da Criança e do Adolescente (NESCA) , Hospital de Clínicas de Porto Alegre , Porto Alegre , Brazil. 2. b Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Faculdade de Medicina , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil. 3. c Departamento de Nutrição, Faculdade de Medicina , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil. 4. d Research Center, Dr von Hauser Children's Hospital , Ludwig-Maximilians-Universität München , Munich , Germany. 5. e Department of Pediatric Cardiology and Intensive Care , Ludwig-Maximilians-Universität München , Munich , Germany. 6. f Departamento de Pediatria, Faculdade de Medicina , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil.
Abstract
Objective: Studies focusing on telomere attrition in newborns and what factors could be involved in this issue are sparse; most reports have been in adult populations. Thereby, the aim of this study was to present an overview of what is currently known about the relationship between environmental exposure of the fetus during pregnancy and telomere length outcomes in early life. Methods: The MEDLINE (via PubMed) and Bireme databases were searched for studies published until 1 June 2016. Studies that reported telomere length measurement from birth to age 1 year were included. Results: Fifteen articles were selected that evaluated possible relationships between maternal smoking, hyperglycemia, hypertension, sleep apnea, psychological stress, folate concentration in early pregnancy, and radiation, in addition to small-for-gestational-age status and preterm birth. We found that sleep apnea, psychological stress, and folate concentration in early pregnancy were associated with telomere shortening in the newborn. No association was found with radiation, small-for-gestational-age status, or preterm birth. Results for maternal smoking, hyperglycemia, and hypertension were conflicting, and further studies should be considered. Conclusion: The actual clinical implications of these findings have yet to be investigated.
Objective: Studies focusing on telomere attrition in newborns and what factors could be involved in this issue are sparse; most reports have been in adult populations. Thereby, the aim of this study was to present an overview of what is currently known about the relationship between environmental exposure of the fetus during pregnancy and telomere length outcomes in early life. Methods: The MEDLINE (via PubMed) and Bireme databases were searched for studies published until 1 June 2016. Studies that reported telomere length measurement from birth to age 1 year were included. Results: Fifteen articles were selected that evaluated possible relationships between maternal smoking, hyperglycemia, hypertension, sleep apnea, psychological stress, folate concentration in early pregnancy, and radiation, in addition to small-for-gestational-age status and preterm birth. We found that sleep apnea, psychological stress, and folate concentration in early pregnancy were associated with telomere shortening in the newborn. No association was found with radiation, small-for-gestational-age status, or preterm birth. Results for maternal smoking, hyperglycemia, and hypertension were conflicting, and further studies should be considered. Conclusion: The actual clinical implications of these findings have yet to be investigated.
Entities:
Keywords:
Early life; intrauterine environment; newborn; pregnancy; telomere attrition
Authors: Desirée Valera-Gran; Daniel Prieto-Botella; Paula Peral-Gómez; Miriam Hurtado-Pomares; Alicia Sánchez-Pérez; Eva-María Navarrete-Muñoz Journal: Int J Environ Res Public Health Date: 2020-06-26 Impact factor: 3.390
Authors: Keith T S Tung; Catherine M W Hung; Ko Ling Chan; Rosa S Wong; Hing Wai Tsang; Wilfred H S Wong; Camilla K M Lo; Winnie W Y Tso; Gilbert T Chua; Benjamin K Yee; Ian C K Wong; W C Leung; Patrick Ip Journal: Oxid Med Cell Longev Date: 2021-09-25 Impact factor: 6.543