Kehan Song1, Xiao Shi2, Xin Liang3, Hongli Wang1, Fei Zou1, Feizhou Lu1, Xiaosheng Ma1, Jianyuan Jiang4. 1. Department of Orthopaedics, Huashan Hospital, Fudan University, No.12 Wulumuqizhong Road, Shanghai, 200040, China. 2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 3. Department of Ophthalmology, Shanghai Medical College, Fudan University, Shanghai, China. 4. Department of Orthopaedics, Huashan Hospital, Fudan University, No.12 Wulumuqizhong Road, Shanghai, 200040, China. jjy@fudanspine.com.
Abstract
PURPOSE: The aim of the study was to investigate risk factors for metastasis at diagnosis. METHODS: We collected patients diagnosed with conventional chondrosarcoma between 1983 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database. Each patient was classified as having metastatic or localized disease. Univariate and multivariate logistic regression analyses were applied to determine which characteristics were risk factors for metastasis at diagnosis. RESULTS: Two thousand three hundred forty-nine patients were collected and 180 patients had metastasis at presentation. Data on age, gender, primary site, grade, and tumour size were enrolled into the multivariate logistic analysis. Greater age (60 years or older: OR = 1.872, 95% CI, 1.206 to 2.904), axial or craniofacial location (spine: OR = 1.775, 95% CI, 1.188 to 2.651; thoracic cage: OR = 2.034, 95% CI, 1.321 to 3.134; craniofacial bones: OR = 5.507, 95% CI, 3.001 to 10.107), higher grade (grade II: OR = 1.849, 95%CI, 1.181 to 2.895; grade III: OR = 4.016, 95%CI, 2.513 to 6.418), and larger tumour size (size over 10 cm: OR = 7.135, 95%CI, 2.130 to 23.893) were associated with an increased risk of metastasis at presentation. CONCLUSIONS: Conventional chondrosarcoma patients with greater age, axial or craniofacial tumour location, higher grade, and larger tumor size were more likely to have metastasis at diagnosis.
PURPOSE: The aim of the study was to investigate risk factors for metastasis at diagnosis. METHODS: We collected patients diagnosed with conventional chondrosarcoma between 1983 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database. Each patient was classified as having metastatic or localized disease. Univariate and multivariate logistic regression analyses were applied to determine which characteristics were risk factors for metastasis at diagnosis. RESULTS: Two thousand three hundred forty-nine patients were collected and 180 patients had metastasis at presentation. Data on age, gender, primary site, grade, and tumour size were enrolled into the multivariate logistic analysis. Greater age (60 years or older: OR = 1.872, 95% CI, 1.206 to 2.904), axial or craniofacial location (spine: OR = 1.775, 95% CI, 1.188 to 2.651; thoracic cage: OR = 2.034, 95% CI, 1.321 to 3.134; craniofacial bones: OR = 5.507, 95% CI, 3.001 to 10.107), higher grade (grade II: OR = 1.849, 95%CI, 1.181 to 2.895; grade III: OR = 4.016, 95%CI, 2.513 to 6.418), and larger tumour size (size over 10 cm: OR = 7.135, 95%CI, 2.130 to 23.893) were associated with an increased risk of metastasis at presentation. CONCLUSIONS: Conventional chondrosarcomapatients with greater age, axial or craniofacial tumour location, higher grade, and larger tumor size were more likely to have metastasis at diagnosis.
Entities:
Keywords:
Bone cancer; Conventional chondrosarcoma; Metastasis; Risk factor
Authors: Hans Gelderblom; Pancras C W Hogendoorn; Sander D Dijkstra; Carla S van Rijswijk; Augustinus D Krol; Antonie H M Taminiau; Judith V M G Bovée Journal: Oncologist Date: 2008-03
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