Maria Didriksen1, Richard P Allen2, Brendan J Burchell3, Lise W Thørner1, Andreas S Rigas1, Emanuele Di Angelantonio4, Maria H Nielsen1, Poul J Jennum5, Thomas Werge6, Christian Erikstrup7, Ole B Pedersen8, Kaspar Nielsen9, Mie T Bruun10, Kristoffer S Burgdorf1, Erik Sørensen1, Henrik Ullum11. 1. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 2. Department of Neurology, John Hopkins University School of Medicine, Baltimore, USA. 3. Faculty of Human, Social and Political Sciences, University of Cambridge, Cambridge, UK. 4. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; National Institute for Health Research, Blood and Transplant Research Unit in Donor Health and Genomics, Cambridge, UK. 5. Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Glostrup, Denmark; Faculty of Health, University of Copenhagen, Copenhagen, Denmark. 6. Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark. 7. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. 8. Department of Clinical Immunology, Nastved Sygehus, Nastved, Denmark. 9. Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark. 10. Department of Clinical Immunology, Odense University Hospital, Odense, Denmark. 11. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: henrik.ullum@regionh.dk.
Abstract
BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications. METHODS: Complete data, including the Cambridge-Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women. RESULTS: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. CONCLUSION: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.
BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications. METHODS: Complete data, including the Cambridge-Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women. RESULTS: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. CONCLUSION: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.
Authors: Thomas Folkmann Hansen; Karina Banasik; Christian Erikstrup; Ole Birger Pedersen; David Westergaard; Piotr Jaroslaw Chmura; Kaspar Nielsen; Lise Thørner; Henrik Hjalgrim; Helene Paarup; Margit Anita Hørup Larsen; Mikkel Petersen; Poul Jennum; Steffen Andersen; Mette Nyegaard; Gregor Borut Ernst Jemec; Jes Olesen; Thomas Werge; Pär I Johansson; Erik Sørensen; Søren Brunak; Henrik Ullum; Kristoffer Sølvsten Burgdorf Journal: BMJ Open Date: 2019-06-09 Impact factor: 2.692
Authors: Maria Didriksen; Muhammad Sulaman Nawaz; Joseph Dowsett; Steven Bell; Christian Erikstrup; Ole B Pedersen; Erik Sørensen; Poul J Jennum; Kristoffer S Burgdorf; Brendan Burchell; Adam S Butterworth; Nicole Soranzo; David B Rye; Lynn Marie Trotti; Prabhjyot Saini; Lilja Stefansdottir; Sigurdur H Magnusson; Gudmar Thorleifsson; Thordur Sigmundsson; Albert P Sigurdsson; Katja Van Den Hurk; Franke Quee; Michael W T Tanck; Willem H Ouwehand; David J Roberts; Eric J Earley; Michael P Busch; Alan E Mast; Grier P Page; John Danesh; Emanuele Di Angelantonio; Hreinn Stefansson; Henrik Ullum; Kari Stefansson Journal: Commun Biol Date: 2020-11-25
Authors: Joseph Dowsett; Maria Didriksen; Margit Hørup Larsen; Khoa Manh Dinh; Kathrine Agergård Kaspersen; Susan Mikkelsen; Lise Wegner Thørner; Erik Sørensen; Christian Erikstrup; Ole Birger Pedersen; Jesper Eugen-Olsen; Karina Banasik; Sisse Rye Ostrowski Journal: PLoS One Date: 2021-11-12 Impact factor: 3.240
Authors: Franziska C Weber; Heidi Danker-Hopfe; Ezgi Dogan-Sander; Lukas Frase; Anna Hansel; Nicole Mauche; Christian Mikutta; Diana Nemeth; Kneginja Richter; Claudia Schilling; Martina Sebestova; Marian M Spath; Christoph Nissen; Thomas C Wetter Journal: Front Psychiatry Date: 2022-03-14 Impact factor: 4.157
Authors: Eric J Earley; Maria Didriksen; Bryan R Spencer; Joseph E Kiss; Christian Erikstrup; Ole B Pedersen; Erik Sørensen; Kristoffer S Burgdorf; Steven H Kleinman; Alan E Mast; Michael P Busch; Henrik Ullum; Grier P Page Journal: Sleep Date: 2021-04-09 Impact factor: 5.849
Authors: Jakob H von Stemann; Ole B Pedersen; Henrik Hjalgrim; Christian Erikstrup; Henrik Ullum; Lise W Thørner; Margit Ah Larsen; Kristoffer S Burgdorf; Erik Sørensen; Morten B Hansen; Sisse R Ostrowski Journal: J Clin Immunol Date: 2020-01-15 Impact factor: 8.317
Authors: Joseph Dowsett; Maria Didriksen; Jakob Hjorth von Stemann; Margit Hørup Larsen; Lise Wegner Thørner; Erik Sørensen; Christian Erikstrup; Ole Birger Pedersen; Morten Bagge Hansen; Jesper Eugen-Olsen; Karina Banasik; Sisse Rye Ostrowski Journal: Sci Rep Date: 2022-01-31 Impact factor: 4.379