| Literature DB >> 29680148 |
Sulejman Alihodžić1, Mirjana Bukvić1, Ivaylo J Elenkov1, Antun Hutinec1, Sanja Koštrun1, Dijana Pešić1, Gordon Saxty1, Linda Tomašković1, Dinko Žiher1.
Abstract
This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in the field assessed. The physicochemical properties, which have provided both successes and challenges, especially in scale-up, are discussed. A recent patent literature is reviewed and the chapter concludes with a perspective on the future of macrocyclic drug discovery.Entities:
Keywords: 3D properties; Drug discovery; Hard target; Increased complexity; Macrocycles; Oral bioavailability; PPI; beyond-Ro5
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Year: 2018 PMID： 29680148 DOI： 10.1016/bs.pmch.2018.01.002
Source DB: PubMed Journal: Prog Med Chem ISSN： 0079-6468