Hongmei Cao1, Johanna Thompson-Westra2, Mark Hallett2, Dietrich Haubenberger3. 1. Department of Neurology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 Yanta Western Road, Xi'an 710061, China; National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA. 2. National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA. 3. National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA. Electronic address: dietrich.haubenberger@nih.gov.
Abstract
OBJECTIVE: To investigate the effect of octanoic acid (OA) on the peripheral component of tremor, as well as OA's differential effects on the central and peripheral tremor component in essential tremor (ET) patients. METHODS: We analyzed postural tremor accelerometry data from a double-blind placebo-controlled cross-over study evaluating the effect of 4 mg/kg OA in ET. The weighted condition was used to identify tremor power for both the central and peripheral tremor components. Exploratory non-parametric statistical analyses were used to describe the relation between the central and peripheral component of tremor power. RESULTS: A peripheral tremor component was identified in 4 out of 18 subjects. Tremor power was reduced after OA administration in both the central and the peripheral tremor component. There was a positive correlation of tremor power between the central and peripheral component, both after placebo and OA. CONCLUSIONS: When present, the peripheral component was closely related to the central tremor component. We hypothesize that the magnitude of the peripheral mechanical component of tremor is determined by that of the central component. SIGNIFICANCE: Both central and peripheral component of tremor are reduced after OA, with the central component providing the energy driving the peripheral component.
RCT Entities:
OBJECTIVE: To investigate the effect of octanoic acid (OA) on the peripheral component of tremor, as well as OA's differential effects on the central and peripheral tremor component in essential tremor (ET) patients. METHODS: We analyzed postural tremor accelerometry data from a double-blind placebo-controlled cross-over study evaluating the effect of 4 mg/kg OA in ET. The weighted condition was used to identify tremor power for both the central and peripheral tremor components. Exploratory non-parametric statistical analyses were used to describe the relation between the central and peripheral component of tremor power. RESULTS: A peripheral tremor component was identified in 4 out of 18 subjects. Tremor power was reduced after OA administration in both the central and the peripheral tremor component. There was a positive correlation of tremor power between the central and peripheral component, both after placebo and OA. CONCLUSIONS: When present, the peripheral component was closely related to the central tremor component. We hypothesize that the magnitude of the peripheral mechanical component of tremor is determined by that of the central component. SIGNIFICANCE: Both central and peripheral component of tremor are reduced after OA, with the central component providing the energy driving the peripheral component.
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