Literature DB >> 2967771

Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain.

M Heilig1, C Wahlestedt, R Ekman, E Widerlöv.   

Abstract

Rats were given imipramine or zimeldine orally for three weeks and the brain levels of neuropeptide Y-like immunoreactivity (NPY-LI) were measured. The concentration of NPY-LI in frontal cortical tissue was elevated by 40 and 60%, respectively. Imipramine increased the concentration of NPY-LI in the hypothalamus by 65% while zimeldine was without effect. The concentration of NPY-LI in the parietal cortex was unaffected by either of the drugs. These observations support the hypothesis that NPY might be involved in the pathophysiology of depressive illness.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2967771     DOI： 10.1016/0014-2999(88)90182-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  19 in total

1.  Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain.

Authors:  A A Mathé; S Gruber; P A Jiménez; E Theodorsson; C Stenfors
Journal:  Neurochem Res       Date:  1997-05       Impact factor: 3.996

Review 2.  Tobacco addiction and the dysregulation of brain stress systems.

Authors:  Adrie W Bruijnzeel
Journal:  Neurosci Biobehav Rev       Date:  2012-03-03       Impact factor: 8.989

3.  Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats.

Authors:  Daria Rylkova; Jeffrey Boissoneault; Shani Isaac; Melissa Prado; Hina P Shah; Adrie W Bruijnzeel
Journal:  Neuropeptides       Date:  2008-05-12       Impact factor: 3.286

Review 4.  Neuropeptide Y and posttraumatic stress disorder.

Authors:  R Sah; T D Geracioti
Journal:  Mol Psychiatry       Date:  2012-07-17       Impact factor: 15.992

5.  Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models.

Authors:  M Heilig; B Söderpalm; J A Engel; E Widerlöv
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  Metabolism and functions of neuropeptide Y.

Authors:  M dos S Medeiros; A J Turner
Journal:  Neurochem Res       Date:  1996-09       Impact factor: 3.996

7.  Contrasting Effects of the Neuropeptides Substance P, Somatostatin, and Neuropeptide Y on the Methamphetamine-Induced Production of Striatal Nitric Oxide in Mice.

Authors:  Lauriaselle Afanador; Haley Yarosh; Jing Wang; Syed F Ali; Jesus A Angulo
Journal:  J Drug Alcohol Res       Date:  2012

Review 8.  Neuropeptides in depression: role of VGF.

Authors:  Smita Thakker-Varia; Janet Alder
Journal:  Behav Brain Res       Date:  2008-10-15       Impact factor: 3.332

9.  Effects of centrally administered neuropeptide Y (NPY) and NPY13-36 on the brain monoaminergic systems of the rat.

Authors:  M Heilig; L Vècséi; C Wahlestedt; C Alling; E Widerlöv
Journal:  J Neural Transm Gen Sect       Date:  1990

10.  Modulation of methamphetamine-induced nitric oxide production by neuropeptide Y in the murine striatum.

Authors:  Haley L Yarosh; Jesus A Angulo
Journal:  Brain Res       Date:  2012-09-13       Impact factor: 3.252
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.