Literature DB >> 29677645

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma.

Timothy M Hall1, Marie-Pier Tétreault2, Kathryn E Hamilton3, Kelly A Whelan4.   

Abstract

Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29677645      PMCID： PMC6108938          DOI： 10.1016/j.coph.2018.04.003

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  58 in total

1.  Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma.

Authors:  Shan Jiang; Yong Li; Ying-Hui Zhu; Xiao-Qi Wu; Jun Tang; Zheng Li; Gong-Kan Feng; Rong Deng; Dan-Dan Li; Rong-Zhen Luo; Mei-Fang Zhang; Wei Qin; Xin Wang; Wei-Hua Jia; Xiao-Feng Zhu
Journal:  Cancer Sci       Date:  2011-05-31       Impact factor: 6.716

2.  A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.

Authors:  Baptiste Ronan; Odile Flamand; Lionel Vescovi; Christine Dureuil; Laurence Durand; Florence Fassy; Marie-France Bachelot; Annabelle Lamberton; Magali Mathieu; Thomas Bertrand; Jean-Pierre Marquette; Youssef El-Ahmad; Bruno Filoche-Romme; Laurent Schio; Carlos Garcia-Echeverria; Hélène Goulaouic; Benoit Pasquier
Journal:  Nat Chem Biol       Date:  2014-10-19       Impact factor: 15.040

3.  Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

Authors:  Nishant Agrawal; Yuchen Jiao; Chetan Bettegowda; Susan M Hutfless; Yuxuan Wang; Stefan David; Yulan Cheng; William S Twaddell; Nyan L Latt; Eun J Shin; Li-Dong Wang; Liang Wang; Wancai Yang; Victor E Velculescu; Bert Vogelstein; Nickolas Papadopoulos; Kenneth W Kinzler; Stephen J Meltzer
Journal:  Cancer Discov       Date:  2012-08-09       Impact factor: 39.397

4.  Beclin 1 expression is associated with the occurrence and development of esophageal squamous cell carcinoma.

Authors:  Hailei Du; Jiamin Che; Minmin Shi; Lianggang Zhu; Jun Biao Hang; Zhongyuan Chen; Hecheng Li
Journal:  Oncol Lett       Date:  2017-09-21       Impact factor: 2.967

5.  Inhibition of autophagy promotes cell apoptosis induced by the proteasome inhibitor MG-132 in human esophageal squamous cell carcinoma EC9706 cells.

Authors:  Donglei Liu; Min Gao; Yang Yang; Y U Qi; Kai Wu; Song Zhao
Journal:  Oncol Lett       Date:  2015-03-17       Impact factor: 2.967

6.  Association of the expression of unc-51-Like kinase 1 with lymph node metastasis and survival in patients with esophageal squamous cell carcinoma.

Authors:  Lin Jiang; Ben-Song Duan; Jun-Xing Huang; Xia Jiao; Xiao-Wei Zhu; Hai-Hui Sheng; Heng-Jun Gao; Hong Yu
Journal:  Int J Clin Exp Med       Date:  2014-05-15

7.  LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers.

Authors:  Akiko Yoshioka; Hiroshi Miyata; Yuichiro Doki; Makoto Yamasaki; Itsuro Sohma; Kunihito Gotoh; Shuji Takiguchi; Yoshiyuki Fujiwara; Yasuo Uchiyama; Morito Monden
Journal:  Int J Oncol       Date:  2008-09       Impact factor: 5.650

8.  Integrated genomic characterization of oesophageal carcinoma.

Authors: 
Journal:  Nature       Date:  2017-01-04       Impact factor: 49.962

9.  Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

Authors:  Ruzica Bago; Nazma Malik; Michael J Munson; Alan R Prescott; Paul Davies; Eeva Sommer; Natalia Shpiro; Richard Ward; Darren Cross; Ian G Ganley; Dario R Alessi
Journal:  Biochem J       Date:  2014-11-01       Impact factor: 3.857

Review 10.  Recent insights into the function of autophagy in cancer.

Authors:  Ravi Amaravadi; Alec C Kimmelman; Eileen White
Journal:  Genes Dev       Date:  2016-09-01       Impact factor: 11.361
View more
  7 in total

Review 1.  A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics.

Authors:  Yuhao Wang; Benjamin Bonavida
Journal:  Crit Rev Oncog       Date:  2018

2.  Prognostic score model based on six m6A-related autophagy genes for predicting survival in esophageal squamous cell carcinoma.

Authors:  Funan Chen; Erxiu Gong; Jun Ma; Jiehuan Lin; Canxing Wu; Shanshan Chen; Shuqiao Hu
Journal:  J Clin Lab Anal       Date:  2022-05-25       Impact factor: 3.124

3.  Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma.

Authors:  Yunsong Chen; Yan Lu; Yanli Ren; Jupeng Yuan; Nasha Zhang; Hannah Kimball; Liqing Zhou; Ming Yang
Journal:  Theranostics       Date:  2020-04-06       Impact factor: 11.556

4.  Silencing of integrin subunit α3 inhibits the proliferation, invasion, migration and autophagy of esophageal squamous cell carcinoma cells.

Authors:  Jin Du; Yang Zhao; Dinghui Hu; Hang Li; Lei Gao; Zuntao Liu; Kaihu Shi
Journal:  Oncol Lett       Date:  2022-06-20       Impact factor: 3.111

5.  Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma.

Authors:  Zhaoming Lu; Yandan Ren; Li Yang; Ang Jia; Yi Hu; Yu Zhao; Wuduo Zhao; Bin Yu; Wen Zhao; Jianying Zhang; Guiqin Hou
Journal:  Acta Pharm Sin B       Date:  2020-12-15       Impact factor: 11.413

6.  Prognostic Significance of Autophagy-Relevant Gene Markers in Colorectal Cancer.

Authors:  Qinglian He; Ziqi Li; Jinbao Yin; Yuling Li; Yuting Yin; Xue Lei; Wei Zhu
Journal:  Front Oncol       Date:  2021-04-15       Impact factor: 6.244

7.  Beclin-1 is a Promising Prognostic Biomarker in a Specific Esophageal Squamous Cell Carcinoma Population.

Authors:  Hailei Du; Fangxiu Luo; Minmin Shi; Jiaming Che; Lianggang Zhu; Hecheng Li; Junbiao Hang
Journal:  Pathol Oncol Res       Date:  2021-04-09       Impact factor: 3.201
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.