Yun Ji1, Baoli Cheng2, Zhipeng Xu2, Hui Ye2, Weina Lu3, Xiaoqian Luo3, Shuiqiao Fu3, Xiangming Fang4. 1. Surgical Intensive Care Unit, Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, China, 310009; Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, China, 310003. 2. Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, China, 310003. 3. Surgical Intensive Care Unit, Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, China, 310009. 4. Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, China, 310003. Electronic address: xmfang@zju.edu.cn.
Abstract
PURPOSE: This study aimed to investigate the association between sarcopenic obesity and 30-day mortality in critically ill patients with intra-abdominal sepsis. MATERIAL AND METHODS: We analyzed 236 surgical ICU patients with sepsis due to intra-abdominal infection who underwent urgent surgical intervention. Sarcopenia, visceral obesity and sarcopenic obesity were analyzed by computed tomography scans using the third lumbar vertebrae skeletal muscle index and visceral adipose tissue area, using previously reported cutoff values. RESULTS: The cohort was divided into 4 groups: 52 were diagnosed with sarcopenic obesity, 62 with sarcopenia only, 58 with visceral obesity only, and 64 with no sarcopenia or visceral obesity. 57 (24.2%) patients died within 30days. The frequency of 30-day mortality differed significantly among the groups. Multivariate analysis showed that only sarcopenic obesity was associated with increased risk for 30-day mortality. Sarcopenic patients were older than non-sarcopenic patients. To address this limitation, subgroup analyses stratified by age showed that the risk of 30-day mortality increased significantly in sarcopenic patients, both in patients with age≤70years and in those with age >70years. CONCLUSION: Sarcopenic obesity is an independent risk factor for 30-day mortality in critically ill patients with intra-abdominal sepsis.
PURPOSE: This study aimed to investigate the association between sarcopenic obesity and 30-day mortality in critically illpatients with intra-abdominal sepsis. MATERIAL AND METHODS: We analyzed 236 surgical ICU patients with sepsis due to intra-abdominal infection who underwent urgent surgical intervention. Sarcopenia, visceral obesity and sarcopenic obesity were analyzed by computed tomography scans using the third lumbar vertebrae skeletal muscle index and visceral adipose tissue area, using previously reported cutoff values. RESULTS: The cohort was divided into 4 groups: 52 were diagnosed with sarcopenic obesity, 62 with sarcopenia only, 58 with visceral obesity only, and 64 with no sarcopenia or visceral obesity. 57 (24.2%) patients died within 30days. The frequency of 30-day mortality differed significantly among the groups. Multivariate analysis showed that only sarcopenic obesity was associated with increased risk for 30-day mortality. Sarcopenic patients were older than non-sarcopenicpatients. To address this limitation, subgroup analyses stratified by age showed that the risk of 30-day mortality increased significantly in sarcopenic patients, both in patients with age≤70years and in those with age >70years. CONCLUSION:Sarcopenic obesity is an independent risk factor for 30-day mortality in critically illpatients with intra-abdominal sepsis.
Authors: Erin F Barreto; Tejaswi Kanderi; Sara R DiCecco; Arnaldo Lopez-Ruiz; Janelle O Poyant; Kristin C Mara; Joy Heimgartner; Ognjen Gajic; Andrew D Rule; Erin M Nystrom; Kianoush B Kashani Journal: JPEN J Parenter Enteral Nutr Date: 2018-12-18 Impact factor: 4.016
Authors: Hakan Kardas; Maximilian Thormann; Caroline Bär; Jazan Omari; Andreas Wienke; Maciej Pech; Alexey Surov Journal: In Vivo Date: 2022 Jan-Feb Impact factor: 2.155
Authors: Sven H Loosen; Maximilian Schulze-Hagen; Tobias Püngel; Lukas Bündgens; Theresa Wirtz; Jakob N Kather; Mihael Vucur; Pia Paffenholz; Münevver Demir; Philipp Bruners; Christiane Kuhl; Christian Trautwein; Frank Tacke; Tom Luedde; Alexander Koch; Christoph Roderburg Journal: Crit Care Explor Date: 2020-08-05
Authors: Robert T Mankowski; Stephen D Anton; Gabriela L Ghita; Babette Brumback; Michael C Cox; Alicia M Mohr; Christiaan Leeuwenburgh; Lyle L Moldawer; Philip A Efron; Scott C Brakenridge; Frederick A Moore Journal: J Am Geriatr Soc Date: 2020-04-15 Impact factor: 5.562
Authors: Balázs Poros; Andrea Sabine Becker-Pennrich; Bastian Sabel; Hans Joachim Stemmler; Dietmar Wassilowsky; Thomas Weig; Ludwig Christian Hinske; Bernhard Zwissler; Jens Ricke; Dominik J Hoechter Journal: Obes Med Date: 2021-07-03