Literature DB >> 29677505

A Mechanosensitive GPCR that Detects the Bloody Force.

Adam J Iliff1, X Z Shawn Xu2.   

Abstract

Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29677505      PMCID： PMC6706248          DOI： 10.1016/j.cell.2018.04.001

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

Review 1.  Feeling force: physical and physiological principles enabling sensory mechanotransduction.

Authors:  Samata Katta; Michael Krieg; Miriam B Goodman
Journal:  Annu Rev Cell Dev Biol       Date:  2015       Impact factor: 13.827

Review 2.  Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels.

Authors:  Reza Sharif-Naeini; Joost H A Folgering; Delphine Bichet; Fabrice Duprat; Patrick Delmas; Amanda Patel; Eric Honoré
Journal:  J Mol Cell Cardiol       Date:  2009-04-01       Impact factor: 5.000

3.  Mechanosensitive channels: in touch with Piezo.

Authors:  Rui Xiao; X Z Shawn Xu
Journal:  Curr Biol       Date:  2010-11-09       Impact factor: 10.834

4.  Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.

Authors:  Bertrand Coste; Jayanti Mathur; Manuela Schmidt; Taryn J Earley; Sanjeev Ranade; Matt J Petrus; Adrienne E Dubin; Ardem Patapoutian
Journal:  Science       Date:  2010-09-02       Impact factor: 47.728

5.  C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.

Authors:  Lijun Kang; Jingwei Gao; William R Schafer; Zhixiong Xie; X Z Shawn Xu
Journal:  Neuron       Date:  2010-08-12       Impact factor: 17.173

6.  Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction.

Authors:  Michael Mederos y Schnitzler; Ursula Storch; Simone Meibers; Pascal Nurwakagari; Andreas Breit; Kirill Essin; Maik Gollasch; Thomas Gudermann
Journal:  EMBO J       Date:  2008-11-06       Impact factor: 11.598

Review 7.  Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology.

Authors:  Peter F Davies
Journal:  Nat Clin Pract Cardiovasc Med       Date:  2008-11-25
  7 in total
  2 in total

Review 1.  The mechanisms of glycolipid metabolism disorder on vascular injury in type 2 diabetes.

Authors:  Xiatian Chen; Chengzhen Shi; Yin Wang; Hua Yu; Yu Zhang; Jiaxuan Zhang; Peifeng Li; Jinning Gao
Journal:  Front Physiol       Date:  2022-08-31       Impact factor: 4.755

Review 2.  Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues.

Authors:  Inmaculada Navarro-Lérida; Anna M Aragay; Alejandro Asensio; Catalina Ribas
Journal:  Antioxidants (Basel)       Date:  2022-08-18
  2 in total

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