Literature DB >> 29677504

Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma.

Christopher J Ricketts1, W Marston Linehan2.   

Abstract

Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.
Copyright © 2018. Published by Elsevier Inc.

Entities:  

Mesh：

Year:  2018        PMID： 29677504     DOI： 10.1016/j.cell.2018.03.077

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  12 in total

1.  Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas.

Authors:  Nadia Bouhamdani; Dominique Comeau; Alexandre Coholan; Kevin Cormier; Sandra Turcotte
Journal:  Carcinogenesis       Date:  2020-07-10       Impact factor: 4.944

2.  Differential VHL Mutation Patterns in Bilateral Clear Cell RCC Distinguishes Between Independent Primary Tumors and Contralateral Metastatic Disease.

Authors:  Cathy D Vocke; Christopher J Ricketts; Adam R Metwalli; Peter A Pinto; Rabindra Gautam; Mark Raffeld; Maria J Merino; Mark W Ball; W Marston Linehan
Journal:  Urology       Date:  2022-04-23       Impact factor: 2.633

3.  The genomic and epigenomic evolutionary history of papillary renal cell carcinomas.

Authors:  Bin Zhu; Maria Luana Poeta; Manuela Costantini; Tongwu Zhang; Jianxin Shi; Steno Sentinelli; Wei Zhao; Vincenzo Pompeo; Maurizio Cardelli; Boian S Alexandrov; Burcak Otlu; Xing Hua; Kristine Jones; Seth Brodie; Malgorzata Ewa Dabrowska; Jorge R Toro; Meredith Yeager; Mingyi Wang; Belynda Hicks; Ludmil B Alexandrov; Kevin M Brown; David C Wedge; Stephen Chanock; Vito Michele Fazio; Michele Gallucci; Maria Teresa Landi
Journal:  Nat Commun       Date:  2020-06-18       Impact factor: 14.919

4.  Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.

Authors:  Ludovica Grassi; Romina Alfonsi; Federica Francescangeli; Michele Signore; Maria Laura De Angelis; Antonio Addario; Manuela Costantini; Elisabetta Flex; Andrea Ciolfi; Simone Pizzi; Alessandro Bruselles; Matteo Pallocca; Giuseppe Simone; Mustapha Haoui; Mario Falchi; Michele Milella; Steno Sentinelli; Paola Di Matteo; Emilia Stellacci; Michele Gallucci; Giovanni Muto; Marco Tartaglia; Ruggero De Maria; Désirée Bonci
Journal:  Cell Death Dis       Date:  2019-02-27       Impact factor: 8.469

5.  TGF‑β1 affects the renal cancer miRNome and regulates tumor cells proliferation.

Authors:  Karolina Hanusek; Beata Rybicka; Piotr Popławski; Anna Adamiok-Ostrowska; Katarzyna Głuchowska; Agnieszka Piekiełko-Witkowska; Joanna Bogusławska
Journal:  Int J Mol Med       Date:  2022-02-18       Impact factor: 4.101

Review 6.  Heterogeneity of the tumor immune microenvironment and its clinical relevance.

Authors:  Qingzhu Jia; Aoyun Wang; Yixiao Yuan; Bo Zhu; Haixia Long
Journal:  Exp Hematol Oncol       Date:  2022-04-23

7.  Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.

Authors:  Laura A Stransky; Sean M Vigeant; Bofu Huang; Destiny West; Thomas Denize; Emily Walton; Sabina Signoretti; William G Kaelin
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-31       Impact factor: 12.779

8.  The up-regulation of NDRG1 by HIF counteracts the cancer-promoting effect of HIF in VHL-deficient clear cell renal cell carcinoma.

Authors:  Zheng-Yan Zhang; Shi-Long Zhang; Hui-Ling Chen; Yu-Qin Mao; Zhan-Ming Li; Chao-Yue Kong; Bing Han; Jin Zhang; Yong-Hui Chen; Wei Xue; Wei Zhai; Li-Shun Wang
Journal:  Cell Prolif       Date:  2020-06-14       Impact factor: 6.831

9.  Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma.

Authors:  Carolin Sauter-Meyerhoff; Regina Bohnert; Pascale Mazzola; Viktoria Stühler; Siarhei Kandabarau; Florian A Büttner; Stefan Winter; Lisa Herrmann; Steffen Rausch; Jörg Hennenlotter; Falko Fend; Marcus Scharpf; Arnulf Stenzl; Stephan Ossowski; Jens Bedke; Matthias Schwab; Elke Schaeffeler
Journal:  Cancers (Basel)       Date:  2021-12-10       Impact factor: 6.639

10.  Significance of CD8+ T cell infiltration-related biomarkers and the corresponding prediction model for the prognosis of kidney renal clear cell carcinoma.

Authors:  Yuan Tian; Yumei Wei; Hongmei Liu; Heli Shang; Yuedong Xu; Tong Wu; Wei Liu; Alan Huang; Qi Dang; Yuping Sun
Journal:  Aging (Albany NY)       Date:  2021-10-04       Impact factor: 5.682
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