Ashley D Perdue1, Lesley A Cottrell2, Christa L Lilly3, William A Gower4, Brian A Ely2, Brad Foringer5, Melvin L Wright2, William A Neal2. 1. a Institute for Community and Rural Health , Morgantown , WV , USA. 2. b Department of Pediatrics , West Virginia University School of Medicine , Morgantown , WV , USA. 3. c Department of Biostatistics , West Virginia University School of Public Health , Morgantown , WV , USA. 4. d Department of Pediatrics , Wake Forest School of Medicine , Winston-Salem , NC , USA. 5. e Division of Respiratory Therapy , West Virginia Hospital Association , Morgantown , WV , USA.
Abstract
RATIONALE: Asthma and obesity are 2 of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk. OBJECTIVES: To examine the relationships between asthma, obesity, and abnormal metabolic indices. METHODS: We conducted a cross-sectional study of 179 children ages 7 to 12 years recruited from a rural, Appalachian region. Our model controlled for children's smoke exposure, body mass index percentile, and gender to examine the association between children's asthma (based on pulmonary function tests, medical history, medications, and parent report of severity), lipids (fasting lipid profile), and measures of altered glucose metabolism (glycosylated hemoglobin and homeostatic model assessment 2-insulin resistance). RESULTS: Our findings revealed a statistically significant model for low density lipids, high density lipids, log triglyceride, and homeostatic model assessment 2-insulin resistance; however, Asthma had a significant effect for the mean triglycerides. We also found an asthma-obesity interaction effect on children's glycosylated hemoglobin with asthmatic obese children revealing significantly higher glycosylated hemoglobin values than non-asthmatic obese children. CONCLUSIONS: Our findings support a connection between asthma and children's glycosylated hemoglobin values; however, this association remains entwined with obesity factors.
RATIONALE: Asthma and obesity are 2 of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk. OBJECTIVES: To examine the relationships between asthma, obesity, and abnormal metabolic indices. METHODS: We conducted a cross-sectional study of 179 children ages 7 to 12 years recruited from a rural, Appalachian region. Our model controlled for children's smoke exposure, body mass index percentile, and gender to examine the association between children's asthma (based on pulmonary function tests, medical history, medications, and parent report of severity), lipids (fasting lipid profile), and measures of altered glucose metabolism (glycosylated hemoglobin and homeostatic model assessment 2-insulin resistance). RESULTS: Our findings revealed a statistically significant model for low densitylipids, high densitylipids, log triglyceride, and homeostatic model assessment 2-insulin resistance; however, Asthma had a significant effect for the mean triglycerides. We also found an asthma-obesity interaction effect on children's glycosylated hemoglobin with asthmatic obesechildren revealing significantly higher glycosylated hemoglobin values than non-asthmatic obesechildren. CONCLUSIONS: Our findings support a connection between asthma and children's glycosylated hemoglobin values; however, this association remains entwined with obesity factors.
Authors: Mary Helen Black; Andrea Anderson; Ronny A Bell; Dana Dabelea; Catherine Pihoker; Sharon Saydah; Michael Seid; Debra A Standiford; Beth Waitzfelder; Santica M Marcovina; Jean M Lawrence Journal: Pediatrics Date: 2011-09-26 Impact factor: 7.124
Authors: Lesley Cottrell; William A Neal; Christa Ice; Miriam K Perez; Giovanni Piedimonte Journal: Am J Respir Crit Care Med Date: 2010-09-17 Impact factor: 21.405
Authors: Sarah L Appleton; Robert J Adams; David H Wilson; Anne W Taylor; Richard E Ruffin Journal: J Allergy Clin Immunol Date: 2006-11-07 Impact factor: 10.793