Literature DB >> 29676205

Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases.

Giuseppe Legname1,2, Tommaso Virgilio3,4, Edoardo Bistaffa1,3, Chiara Maria Giulia De Luca3, Marcella Catania3, Paola Zago1, Elisa Isopi1, Ilaria Campagnani3, Fabrizio Tagliavini3, Giorgio Giaccone3, Fabio Moda3.   

Abstract

Pin1 is a peptidyl-prolyl isomerase that induces the cis-trans conversion of specific Ser/Thr-Pro peptide bonds in phosphorylated proteins, leading to conformational changes through which Pin1 regulates protein stability and activity. Since down-regulation of Pin1 has been described in several neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), we investigated its potential role in prion diseases. Animals generated on wild-type (Pin1+/+), hemizygous (Pin1+/-) or knock-out (Pin1-/-) background for Pin1 were experimentally infected with RML prions. The study indicates that, neither the total depletion nor reduced levels of Pin1 significantly altered the clinical and neuropathological features of the disease.

Entities:  

Keywords:  PMCA; Pin1; neurodegeneration; prion

Mesh：

Substances：

Year:  2018        PMID： 29676205      PMCID： PMC6016513          DOI： 10.1080/19336896.2018.1464367

Source DB:  PubMed          Journal:  Prion        ISSN： 1933-6896            Impact factor:   3.931


  62 in total

1.  PrP glycoforms are associated in a strain-specific ratio in native PrPSc.

Authors:  Azadeh Khalili-Shirazi; Linda Summers; Jacqueline Linehan; Gary Mallinson; David Anstee; Simon Hawke; Graham S Jackson; John Collinge
Journal:  J Gen Virol       Date:  2005-09       Impact factor: 3.891

2.  Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

Authors:  F Fujimori; K Takahashi; C Uchida; T Uchida
Journal:  Biochem Biophys Res Commun       Date:  1999-11-30       Impact factor: 3.575

3.  Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein.

Authors:  L W Xiong; L D Raymond; S F Hayes; G J Raymond; B Caughey
Journal:  J Neurochem       Date:  2001-11       Impact factor: 5.372

4.  Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake.

Authors:  Hanna Wolf; Andrea Graßmann; Romina Bester; André Hossinger; Christoph Möhl; Lydia Paulsen; Martin H Groschup; Hermann Schätzl; Ina Vorberg
Journal:  J Virol       Date:  2015-07-22       Impact factor: 5.103

5.  Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.

Authors:  John P Anderson; Donald E Walker; Jason M Goldstein; Rian de Laat; Kelly Banducci; Russell J Caccavello; Robin Barbour; Jiping Huang; Kristin Kling; Michael Lee; Linnea Diep; Pamela S Keim; Xiaofeng Shen; Tim Chataway; Michael G Schlossmacher; Peter Seubert; Dale Schenk; Sukanto Sinha; Wei Ping Gai; Tamie J Chilcote
Journal:  J Biol Chem       Date:  2006-07-17       Impact factor: 5.157

6.  The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer.

Authors:  Gustavo Ayala; Dagong Wang; Gerburg Wulf; Anna Frolov; Rile Li; Janusz Sowadski; Thomas M Wheeler; Kun Ping Lu; Lere Bao
Journal:  Cancer Res       Date:  2003-10-01       Impact factor: 12.701

7.  Protein misfolding cyclic amplification of infectious prions.

Authors:  Rodrigo Morales; Claudia Duran-Aniotz; Rodrigo Diaz-Espinoza; Manuel V Camacho; Claudio Soto
Journal:  Nat Protoc       Date:  2012-06-28       Impact factor: 13.491

Review 8.  Molecular biology and genetics of prion diseases.

Authors:  S B Prusiner
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1994-03-29       Impact factor: 6.237

Review 9.  Protein misfolding and neurodegeneration.

Authors:  Claudio Soto; Lisbell D Estrada
Journal:  Arch Neurol       Date:  2008-02

10.  Continuous quinacrine treatment results in the formation of drug-resistant prions.

Authors:  Sina Ghaemmaghami; Misol Ahn; Pierre Lessard; Kurt Giles; Giuseppe Legname; Stephen J DeArmond; Stanley B Prusiner
Journal:  PLoS Pathog       Date:  2009-11-26       Impact factor: 6.823
View more
  2 in total

Review 1.  Application of yeast to studying amyloid and prion diseases.

Authors:  Yury O Chernoff; Anastasia V Grizel; Aleksandr A Rubel; Andrew A Zelinsky; Pavithra Chandramowlishwaran; Tatiana A Chernova
Journal:  Adv Genet       Date:  2020-05-04       Impact factor: 1.944

Review 2.  The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: from Neurodevelopment to Neurodegeneration.

Authors:  Francesca Fagiani; Stefano Govoni; Marco Racchi; Cristina Lanni
Journal:  Mol Neurobiol       Date:  2020-10-21       Impact factor: 5.590
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.