K Bolhuis1,2, M E Koopman-Verhoeff1,2, L M E Blanken1, D Cibrev1, V W V Jaddoe3,4, F C Verhulst1,5, M H J Hillegers1,6, S A Kushner7, H Tiemeier1,8. 1. Department of Child & Adolescent Psychiatry, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands. 2. Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands. 3. Department of Paediatrics, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands. 4. Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands. 5. Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark. 6. Department of Psychiatry, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands. 7. Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands. 8. Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Abstract
OBJECTIVE: Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years. METHOD: This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire. Mothers reported problems of their child at ages 3, 6 and 10 years. Additionally, mothers were interviewed about their child's adversities. RESULTS: Psychotic-like experiences were endorsed by ~20% of children and predicted by both emotional and behavioural problems at 3 years (e.g. emotional-reactive problems: ORadjusted = 1.10, 95% CI: 1.06-1.15, aggressive behaviour: ORadjusted = 1.03, 95% CI: 1.02-1.05) and 6 years (e.g. anxious/depressed problems: ORadjusted = 1.11, 95% CI: 1.06-1.15, aggressive behaviour: ORadjusted = 1.04, 95% CI: 1.04-1.05). Childhood adversities were associated with psychotic-like experiences (>2 adversities: ORadjusted = 2.24, 95% CI: 1.72-2.92), which remained significant after adjustment for comorbid psychiatric problems. CONCLUSION: This study demonstrated associations between early adversities, childhood emotional and behavioural problems and pre-adolescent psychotic-like experiences, which will improve the understanding of children at increased risk of severe mental illness.
OBJECTIVE: Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years. METHOD: This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire. Mothers reported problems of their child at ages 3, 6 and 10 years. Additionally, mothers were interviewed about their child's adversities. RESULTS:Psychotic-like experiences were endorsed by ~20% of children and predicted by both emotional and behavioural problems at 3 years (e.g. emotional-reactive problems: ORadjusted = 1.10, 95% CI: 1.06-1.15, aggressive behaviour: ORadjusted = 1.03, 95% CI: 1.02-1.05) and 6 years (e.g. anxious/depressed problems: ORadjusted = 1.11, 95% CI: 1.06-1.15, aggressive behaviour: ORadjusted = 1.04, 95% CI: 1.04-1.05). Childhood adversities were associated with psychotic-like experiences (>2 adversities: ORadjusted = 2.24, 95% CI: 1.72-2.92), which remained significant after adjustment for comorbid psychiatric problems. CONCLUSION: This study demonstrated associations between early adversities, childhood emotional and behavioural problems and pre-adolescent psychotic-like experiences, which will improve the understanding of children at increased risk of severe mental illness.
Authors: Lisa R Steenkamp; Henning Tiemeier; Koen Bolhuis; Manon H J Hillegers; Steven A Kushner; Laura M E Blanken Journal: Acta Psychiatr Scand Date: 2021-02-16 Impact factor: 6.392
Authors: Lisa R Steenkamp; Koen Bolhuis; Laura M E Blanken; Maartje P C M Luijk; Manon H J Hillegers; Steven A Kushner; Henning Tiemeier Journal: J Child Psychol Psychiatry Date: 2020-06-19 Impact factor: 8.982
Authors: Lisa R Steenkamp; Henning Tiemeier; Laura M E Blanken; Manon H J Hillegers; Steven A Kushner; Koen Bolhuis Journal: Br J Psychiatry Date: 2021-12 Impact factor: 9.319
Authors: Koen Bolhuis; Lisa R Steenkamp; Laura M E Blanken; Alexander Neumann; Philip R Jansen; Manon H J Hillegers; Charlotte A M Cecil; Henning Tiemeier; Steven A Kushner Journal: Eur Child Adolesc Psychiatry Date: 2021-02-26 Impact factor: 4.785